Table 2. Regression analysis of predictors for 90 days survival of ICU admitted lung cancer patients.
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Demographics | ||||
| Age (years) | 0.98 (0.96, 1.00) | 0.014 | 0.96 (0.94, 0.98) | <0.001 |
| Gender, n (%) | ||||
| Female | Ref. | Ref. | ||
| Male | 1.18 (0.78, 1.77) | 0.429 | 0.72 (0.47, 1.12) | 0.146 |
| BMI (kg/m2) | 0.90 (0.85, 0.95) | <0.001 | 0.92 (0.87, 0.97) | 0.002 |
| Treatment history | ||||
| Target therapy | 2.34 (1.59, 3.44) | <0.001 | – | – |
| Immunotherapy | 2.13 (1.38, 3.30) | <0.001 | – | – |
| Chemotherapy | 1.64 (1.14, 2.37) | 0.008 | 0.57 (0.37, 0.87) | 0.009 |
| Radiotherapy | 2.15 (1.23, 3.76) | 0.007 | – | – |
| Transferring source | ||||
| Operation room | Ref. | Ref. | ||
| Emergency department | 28.38 (8.00, 100.70) | <0.001 | 9.78 (2.22, 43.14) | 0.003 |
| Clinical ward | 19.53 (6.19, 61.62) | <0.001 | 6.41 (1.61, 25.62) | 0.009 |
| Other hospitals | 14.32 (3.20, 64.03) | <0.001 | 2.05 (0.36, 11.81) | 0.423 |
| Planned transfer | 0.08 (0.03, 0.19) | <0.001 | – | – |
| Elective or emergency surgery | ||||
| No surgery | Ref. | Ref. | ||
| Elective | 0.14 (0.08, 0.25) | <0.001 | 0.38 (0.20, 0.69) | 0.002 |
| Emergency | 1.22 (0.39, 3.84) | 0.738 | 2.28 (0.57, 9.12) | 0.242 |
| Severity scores | ||||
| SOFA | 1.19 (1.14, 1.24) | <0.001 | 1.05 (1.00, 1.12) | 0.064 |
| APACHE II | 1.07 (1.05, 1.09) | <0.001 | – | – |
| ICU diagnosis | ||||
| Sepsis | 10.16 (4.47, 23.11) | <0.001 | 2.61 (1.02, 6.67) | 0.045 |
| ARDS | 2.85 (1.96, 4.15) | <0.001 | ||
| Respiratory failure | 4.98 (3.24, 7.66) | <0.001 | 2.16 (1.29, 3.62) | 0.003 |
| AKI | ||||
| None | Ref. | |||
| Grade I | 2.03 (0.94, 4.39) | 0.070 | 1.12 (0.50, 2.49) | 0.779 |
| Grade II | 3.82 (1.92, 7.61) | <0.001 | 2.83 (1.32, 6.06) | 0.008 |
| Grade III | 4.93 (2.63, 9.26) | <0.001 | 2.5 (1.23, 5.10) | 0.012 |
| Anti-infection treatment | ||||
| Carbapenems | 3.09 (2.16, 4.42) | <0.001 | 1.46 (0.97, 2.20) | 0.073 |
| β-lactam | 1.62 (1.13, 2.32) | 0.009 | – | – |
| Glycopeptides | 2.22 (1.45, 3.40) | <0.001 | – | – |
| Tigecycline | 2.38 (1.21, 4.71) | 0.012 | – | – |
| Echinocandins | 1.96 (1.12, 3.43) | 0.018 | – | – |
| Triazoles | 2.65 (1.80, 3.91) | <0.001 | – | – |
| Other treatment | ||||
| Mechanical ventilation | 3.90 (2.64, 5.76) | <0.001 | – | – |
| Conventional oxygen therapy | 0.15 (0.10, 0.21) | <0.001 | 0.31 (0.20, 0.49) | <0.001 |
| Sedation treatment | 3.96 (2.75, 5.69) | <0.001 | – | – |
Notes.
Cox regression tests were applied to analyze the correlated factors of 90 days death outcomes. Factors with significant correlation identified in univariate analysis, along with age and gender, were then incorporated in backward stepwise multivariate regression analysis to identify independent associated variables.
TITLE
- BMI
- Body Mass Index
- SOFA
- Sequential Organ Failure Assessment
- APACHE
- II Acute Physiology And Chronic Health Evaluation II
- ARDS
- Acute Respiratory Distress Syndrome
- AKI
- Acute Kidney Injury