Table 3.

Mild cognitive impairment diagnosis performance.

System number	Name of the gamified interactive system	Reference	Game metrics	Sensitivity (%)	Specificity (%)	AUCa
Sys3	VAP-Sb	[54]	Features extracted from trajectory, region, and task performance	100	100	1
Sys4	VREAD	[55]	Correct path, incorrect path, correct sequences, incorrect sequences, overall score, and time	75	96	—c
Sys6	SmartAging	[63]	Smart Aging Total Score	—	—	0.99
Sys6	SmartAging	[64]	Smart Aging Serious Game total score	84.4	75.5	0.88
Sys7	FitForAll	[67]	Evaluator-ranked age, HRMGd mean total, HRMG intercept total, HRMG mean level 1, HRMG mean level3, HRMG mean level 4, and heart rate slope level 3	—	—	0.77
Sys9	Find the pair	[69]	Game trials	83	62	—
Sys9	Find the pair	[69]	Game time	82	67	—c
Sys16	—	[79]	Best cutoff game points based on MoCAe	88	77.8	—c
Sys16	—	[79]	Best cutoff game points based on MoCA	87.5	33.3	—c
Sys17	Dr. Solitaire	[83]	Nu-support vector classifier using digital biomarkers of cognitive performance in Klondike Solitaire	77.8	88.9	0.9
Sys20	Panoramix	[90]	Random forest using Panoramix battery	100	100	0.98
Sys20	Panoramix	[91]	Support vector machine using Panoramix (version 2.0) battery	100	100	—
Sys25	RE@CH	[98]	Total performance score	78.2	75.7	0.82
Sys28	Holey Moley	[101]	Holey Moley game classification based on MMSEf	100	97.2	0.95
Sys30	Virtual Supermarket	[104]	Score in the Virtual Supermarket Program	85.9	79	0.87
Sys30	Virtual Supermarket	[105]	All Virtual Supermarket variables	76.3	91.4	—
Sys30	Virtual Supermarket	[106]	All Virtual Supermarket variables	74	85	—
Sys30	Virtual Supermarket	[106]	All bought unlisted, correct money, and duration	79	86	—
Sys33	Lucy	[109]	Focused attention response profile and EEGg characteristics	80	82.6	—
Sys36	COGNIPLAT	[113]	Support vector machine using 9 variables	91.8	93.2	—
Sys36	COGNIPLAT	[114]	Manually selected feature set with 9 features: age, family medical history, exercising, education, average game round time in game session, orientation game importance, naming game importance, memory game importance, and recall (Anakilisi) game importance	96.6	90	0.99
Sys48	The Ryokansan	[127]	Flipping cards game score	76.9	70.7	—
Sys48	The Ryokansan	[127]	Game score from the “finding mistakes” task	70.7	56.5	—

^aAUC: area under the curve.

^bVAP-S: virtual action planning supermarket.

^cNot available.

^dHRMG: high-resolution monitoring games.

^eMoCA: Montreal Cognitive Assessment.

^fMMSE: Mini-Mental State Examination.

^gEEG: electroencephalogram.