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Specificity of the RNA targeting system. (A) Structures of the small molecules used in this study. (B) Characterization of s23. Binding of the s23 aptamer to the 4G-, 8G- or 2A-tFKBP*3R complexes is indicated as a percentage of binding to tFKBP*3R-2G. s23 is highly specific for tFKBP*3R-2G relative to all other protein-small molecule combinations tested. A representative blot is shown above the graph.
