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. 2005 Sep 30;33(17):5602–5610. doi: 10.1093/nar/gki867

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Truncation and mutational analysis of s23. (A) The bases comprising the s23 truncations T1, T2 and T3 are boxed. Truncation variants T1 and T2 bind tFKBP*3R-2G with affinities similar to that of the full-length s23, but complete removal of Stem II in variant T3 results in greatly weakened binding. (B) Point or double mutations that were introduced into s23. Modifications that result in a K_d over 350 nM are indicated in blue; those that bind with tighter affinities are colored orange. (C) Binding affinities of s23 mutations and truncations that are tolerated by the tFKBP*3R-2G complex.