Table 1.
Recovery and precision of vancomycin in intracellular and extracellular fluids (n = 5).
| Conditions | Concentration (mg/mL) | Absolute recovery | Relative recovery | Intraday precision | Interday precision | ||||
|---|---|---|---|---|---|---|---|---|---|
| M e a n ± SD (%) | RSD (%) | M e a n ± SD (%) | RSD (%) | Measured (mg/mL) | RSD (%) | Measured (mg/mL) | RSD (%) | ||
| Intracellular fluid | 0.01 | 79.81 ± 0.87 | 1.09 | 85.47 ± 1.70 | 1.99 | 0.0114 ± 0.00048 | 5.18 | 0.0114 ± 0.0009 | 8.65 |
| 1 | 93.97 ± 2.48 | 2.64 | 97.30 ± 1.41 | 1.45 | 1.09 ± 0.04 | 3.61 | 1.09 ± 0.16 | 14.59 | |
| 6.4 | 88.23 ± 3.99 | 4.52 | 84.98 ± 3.93 | 4.62 | 6.67 ± 0.40 | 6.01 | 6.95 ± 0.35 | 5.02 | |
|
| |||||||||
| Extracellular fluid | 0.01 | 92.75 ± 4.11 | 4.43 | 85.33 ± 4.14 | 4.86 | 0.0105 ± 0.00088 | 8.37 | 0.0103 ± 0.00097 | 9.38 |
| 1 | 97.09 ± 4.13 | 4.25 | 99.84 ± 3.38 | 3.38 | 1.10 ± 0.05 | 4.49 | 1.11 ± 0.15 | 13.36 | |
| 6.4 | 97.78 ± 0.64 | 0.65 | 94.50 ± 0.60 | 0.64 | 6.47 ± 0.21 | 3.24 | 6.52 ± 0.27 | 4.11 | |
Abbreviations: RSD, relative standard deviation; SD, standard deviation.