Table 2.
Stability of vancomycin in intracellular and extracellular fluids (n = 5).
| Treatment | Concentration (mg/mL) | Intracellular fluid | Extracellular fluid | ||
|---|---|---|---|---|---|
| Founded (mg/mL) | RSD (%) | Founded (mg/mL) | RSD (%) | ||
| Storage at −40°C for 3 days | 0.01 | 0.0113 ± 0.0003 | 2.55 | 0.0103 ± 0.0006 | 6.13 |
| 1 | 1.12 ± 0.03 | 2.57 | 1.04 ± 0.02 | 1.79 | |
| 6.4 | 6.83 ± 0.10 | 1.50 | 6.64 ± 0.34 | 5.18 | |
|
| |||||
| Three freeze-thaw cycles | 0.01 | 0.0109 ± 0.0009 | 8.13 | 0.0105 ± 0.0010 | 9.36 |
| 1 | 0.90 ± 0.02 | 2.20 | 0.94 ± 0.03 | 2.83 | |
| 6.4 | 6.35 ± 0.24 | 3.75 | 6.88 ± 0.07 | 1.02 | |
|
| |||||
| Immediately determine | 0.01 | 0.0105 ± 0.0004 | 3.75 | 0.0105 ± 0.0007 | 6.42 |
| 1 | 1.05 ± 0.01 | 1.04 | 1.12 ± 0.03 | 2.80 | |
| 6.4 | 6.51 ± 0.54 | 8.23 | 6.37 ± 0.05 | 0.78 | |
Abbreviation: RSD, relative standard deviation.