TABLE 3.
Kill metrics of ciprofloxacin compared with β-lactamsa
| Duration of bacteriostasis | Half-life in first kill phase | MDK99 | Proportion of cells in second kill phase | |
|---|---|---|---|---|
| (T0 – min) | (ln2/k1 – min) | (min) | (P – n/105 CFU) | |
| CIP | 0b | 3.1 (2.2-4.0) | 19.3 (14.8-23.7) | 7.7 (0.4-14.9) |
| β-lactams | 56.7 (52.2-61.1) | 3.2 (2.4-4.0) | 75.0 (70.5-79.4) | 26.1 (17.6-34.7) |
| P-value | 9.8 × 10−4 | NS | 4.9 × 10−4 | 0.012 |
a
Mean values from 15 clinical isolates; 95% CI is indicated within parentheses. P-values were calculated using the Wilcoxon-signed rank test; NS signifies a non-significant result, i.e., P > 0.05.
b
CIP experimental data was fitted without an initial bacteriostatic phase.