Table 3.
Changes in clinical and biologic parameters after treatment with hydroxyurea
| Settings | Starting Values | Evolution over Time | P Value | ||
|---|---|---|---|---|---|
| 3 mo Later | 6 mo Later | 9 mo Later | |||
| No. of transfusion | 7.4±6.7 | 1.8±1.4 | 0.4±0.5 | 0.1±0.3 | <0.001 |
| No. of VOC | 1.8±1.1 | 1.1±0.8 | 0.5±0.5 | 0.2±0.4 | 0.03 |
| BMI, kg/m2 | 15.8±4.3 | 16.1±5.1 | 17.2±3.2 | 18.3±3.1 | 0.02 |
| ACR | 122.5±16.3 | 59.1±28.8 | 31.5±2.6 | 30±2.4 | 0.002 |
| Cr | 0.4±0.4 | 0.3±0.4 | 0.4±0.4 | 0.6±0.4 | 0.053 |
| eGFR, ml/min per 1.73 m2 | 128.9±69.1 | 112.2±21.1 | 108±11.1 | 92.86±4.8 | 0.02 |
| GHF, n (%) | 9 (30) | 6 (20) | 4 (13.3) | 1 (3.3) | <0.001 |
| LDH, mg/dl | 1726.2±752.7 | 1225.1±353.7 | 817.3±151.2 | 503.5±113.4 | 0.003 |
| BI, mg/dl | 2.8±1.5 | 1.8±1.2 | 1.3±1.1 | 0.7±0.2 | 0.023 |
| HbF, % | 10±7.4 | 12.1±5.8 | 14.4±5.1 | 18.8±4.9 | <0.001 |
ACR, albuminuria/creatinuria ratio; BI, indirect bilirubin; BMI, body mass index; Cr, creatinine; GHF, glomerular hyperfiltration ≥135 ml/min per 1.73 m2 SC; HbF, fetal hemoglobin; LDH, lactate dehydrogenase; VOC, vaso-occlusive crisis.