Extended Data Fig. 2:

Performance of excess C and maximum %T scores. Related to Fig. 2. a, Cumulative distribution of maximum CG skew in 150 nt windows, separated by fragments (length ≥ 150 bp) with (dotted purple line; n = 9,983) and without (solid grey line; n = 136,728) Rho termination activity. AUC, area under ROC curve (Methods). Light blue shaded region indicates maximum CG skews considered in c. b, As in a, but for the excess C score, which is the sum of all positive CG skews in 150-nt windows tiling the fragment (Methods). Orange shaded region indicates excess C score of fragments shown in d and e. c, As in b, for fragments with a maximum CG score between 0.37 and 0.40 (region highlighted in blue in a). Non-terminated and Rho-terminated fragments with very similar maximum CG skews are separated by their excess C scores. d, Distribution of enrichments for fragments (length ≥ 150 bp) with an excess C score between 0.50 and 0.55. Below det., below detection (Methods). e, Cumulative distribution of maximum %T score for fragments with an excess C score between 0.50 and 0.55, separated by fragments with (dotted purple line; n = 9,983) and without (solid grey line; n = 136,728) Rho termination activity. Fragments with very similar excess C scores are separated by their maximum %T score.