TABLE 3.
MCA of the effects of various parameters on flux (J) through the glycerol synthesis pathway
Metabolic control coefficienta | Value at the following phase of growth:
|
||
---|---|---|---|
Early exponentialb | Mid-exponentialc | Early stationaryd | |
Response coefficients | |||
RNADHJ | 0.03 | 0.05 | 0.08 |
RDHAPJ | 0.48 | 0.60 | 0.69 |
RNADJ | −0.02 | −0.02 | −0.03 |
RF1,6BPJ | −0.16 | −0.11 | −0.10 |
RATPJ | −0.42 | −0.50 | −0.21 |
RADPJ | −0.14 | −0.10 | −0.14 |
Flux control coefficients | |||
Cv1J | 0.85 | 0.88 | 0.83 |
Cv2J | 0.15 | 0.12 | 0.17 |
Metabolic control coefficients were calculated by the Gepasi simulated model of the glycerol synthesis pathway. v1, rate of Gpd p-catalyzed reaction; v2, rate of Gpp p-catalyzed reaction.
OD600, 0.4 [400 to 430 min].
OD600, 0.7 [600 to 630 min].
OD600, 1.1 [970 to 1,000 min].