FIG. 1.

(A) Comparison of conserved adenylation motifs (A3 to A10) and the conserved thiolation motif (T), as defined by Konz and Marahiel (27), for peptide synthetases (upper line) with motifs found in the syringomycin synthetase encoded by syrE (19) (middle line) and with the motifs identified in the sequenced part of the amphisin synthetase encoded by amsY (lower line). Residues in amphisin synthetase corresponding to one or both of the sequences used for comparison are in bold. (B) Comparison of one of the three leucine-specific consensus sequences found in the leucine binding domains of BacA, LicA, LchAA, LicB, LchAB, SrfAA, and SrfAB (52) with the corresponding residues in the sequenced part of amphisin synthetase.