Table 2.
Multivariate logistic regression analysis of the influencing factors for cryptogenic stroke related to patent foramen ovale (PFO) in general.
| Variables | CS vs. NS | CS vs. NCS | ||||||
|---|---|---|---|---|---|---|---|---|
| B | P-value | OR | 95%CI | B | P-value | OR | 95%CI | |
| PFO diameter | 0.795 | 0.001 | 2.215 | 1.375–3.568 | 0.441 | 0.028 | 1.554 | 1.050–2.299 |
| WBC | 0.229 | 0.043 | 1.258 | 1.007–1.571 | 0.052 | 0.588 | 1.053 | 0.873–1.270 |
| HbA1c | 0.444 | 0.198 | 1.558 | 0.793–3.063 | 0.404 | 0.129 | 1.498 | 0.889–2.522 |
| Age | ||||||||
| Age < 60 | −2.110 | 0.004 | 0.121 | 0.028–0.518 | −0.709 | 0.287 | 0.492 | 0.133–1.816 |
| Age ≥ 60 | 8.264 | 1.931–35.71 | 2.033 | 0.551–7.519 | ||||
| Diabetes | ||||||||
| No | −0.231 | 0.806 | 0.794 | 0.126–5.021 | 0.799 | 0.279 | 2.223 | 0.523–9.444 |
| Yes | 1.259 | 0.199–7.937 | 0.450 | 0.106–1.912 | ||||
| Previous Stroke/TIA | ||||||||
| No | −19.091 | 0.989 | –a | –a | −1.026 | 0.045 | 0.358 | 0.131–0.979 |
| Yes | 2.793 | 1.021–7.634 | ||||||
| Cortical infarct on imaging | ||||||||
| No | −20.435 | <0.001 | –a | –a | −2.118 | <0.001 | 0.120 | 0.038–0.384 |
| Yes | 8.333 | 2.604–26.32 | ||||||
| Small RLS | −0.577 | 0.346 | 0.561 | 0.169–1.865 | −1.590 | 0.004 | 0.204 | 0.070–0.595 |
| Large RLS | 4.902 | 1.681–14.29 | ||||||
a
Odds ratio not calculable due to complete separation.
NS, no stroke; CS, cryptogenic stroke; NCS, non-cryptogenic stroke; TIA, transient ischemic attack; RLS, right-to-left shunt; PFO, patent foramen ovale; WBC, white blood cell count; HbA1c, glycated hemoglobin A1c.