Abstract
Research on environmentally related chemical contaminants in breast milk spans several decades and dozens of countries. The ability to use this research as an environmental indicator is limited because of a lack of consistent protocols. Data on xenobiotics in breast milk are influenced by choices in sample selection, sample pooling, analysis, and reporting. In addition, most studies have focused only on a small panel of persistent organic pollutants, despite indications that a wide range of additional chemical contaminants may also enter breast milk. Despite these limitations, however, it is possible to draw some generalizations. In this paper we review available data on levels of organochlorine pesticides, polychlorinated biphenyls (PCBs), polychlorinated dibenzodioxins (PCDDs), polybrominated diphenyl ethers (PBDEs), metals, and solvents in breast milk. Examples drawn from around the world illustrate the available data and the patterns that have appeared in various areas over time. Over the past few decades, levels of the organochlorine pesticides, PCBs, and dioxins have declined in breast milk in countries where these chemicals have been banned or otherwise regulated. In contrast, the levels of PBDEs are rising. Regional differences in levels of xenobiotics in breast milk are related to historical and current local use patterns. Diet is a major factor that influences breast milk levels of persistent organic pollutants, with patterns in fish consumption playing a particularly significant role. Improved global breast milk monitoring programs would allow for more consistent data on trends over time, detection of new xenobiotics in breast milk, and identification of disproportionately exposed populations.
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- Albert L., Vega P., Portales A. Organochlorine pesticide residues in human milk samples from Comarca Lagunera, Mexico, 1976. Pestic Monit J. 1981 Dec;15(3):135–138. [PubMed] [Google Scholar]
- Bagnell P. C., Ellenberger H. A. Obstructive jaundice due to a chlorinated hydrocarbon in breast milk. Can Med Assoc J. 1977 Nov 5;117(9):1047–1048. [PMC free article] [PubMed] [Google Scholar]
- Beck H., Dross A., Mathar W. PCDD and PCDF exposure and levels in humans in Germany. Environ Health Perspect. 1994 Jan;102 (Suppl 1):173–185. doi: 10.1289/ehp.94102s1173. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bradt P. T., Herrenkohl R. C. DDT in human milk. What determines the levels? Sci Total Environ. 1976 Sep;6(2):161–163. doi: 10.1016/0048-9697(76)90011-5. [DOI] [PubMed] [Google Scholar]
- Brevik E. M., Bjerk J. E. Organochlorine compounds in Norwegian human fat and milk. Acta Pharmacol Toxicol (Copenh) 1978 Jul;43(1):59–63. doi: 10.1111/j.1600-0773.1978.tb02233.x. [DOI] [PubMed] [Google Scholar]
- Brouwer A., Ahlborg U. G., van Leeuwen F. X., Feeley M. M. Report of the WHO working group on the assessment of health risks for human infants from exposure to PCDDs, PCDFs and PCBs. Chemosphere. 1998 Oct-Nov;37(9-12):1627–1643. doi: 10.1016/s0045-6535(98)00230-6. [DOI] [PubMed] [Google Scholar]
- Chikuni O., Polder A., Skaare J. U., Nhachi C. F. An evaluation of DDT and DDT residues in human breast milk in the Kariba Valley of Zimbabwe. Bull Environ Contam Toxicol. 1997 May;58(5):776–778. doi: 10.1007/s001289900401. [DOI] [PubMed] [Google Scholar]
- Clench-Aas J., Bartonova A., Oehme M., Lindstrøm G. PCDD and PCDF in human milk from Scandinavia, with special emphasis on Norway. J Toxicol Environ Health. 1992 Sep;37(1):73–83. doi: 10.1080/15287399209531658. [DOI] [PubMed] [Google Scholar]
- Courtney K. D. Hexachlorobenzene (HCB): a review. Environ Res. 1979 Dec;20(2):225–266. doi: 10.1016/0013-9351(79)90001-x. [DOI] [PubMed] [Google Scholar]
- Craan A. G., Haines D. A. Twenty-five years of surveillance for contaminants in human breast milk. Arch Environ Contam Toxicol. 1998 Nov;35(4):702–710. doi: 10.1007/s002449900434. [DOI] [PubMed] [Google Scholar]
- Cripps D. J., Peters H. A., Gocmen A., Dogramici I. Porphyria turcica due to hexachlorobenzene: a 20 to 30 year follow-up study on 204 patients. Br J Dermatol. 1984 Oct;111(4):413–422. doi: 10.1111/j.1365-2133.1984.tb06603.x. [DOI] [PubMed] [Google Scholar]
- Currie R. A., Kadis V. W., Breitkreitz W. E., Cunningham G. B., Bruns G. W. Pesticide residues in human milk, Alberta, Canada--1966-70, 1977-78. Pestic Monit J. 1979 Sep;13(2):52–55. [PubMed] [Google Scholar]
- Darnerud P. O., Eriksen G. S., Jóhannesson T., Larsen P. B., Viluksela M. Polybrominated diphenyl ethers: occurrence, dietary exposure, and toxicology. Environ Health Perspect. 2001 Mar;109 (Suppl 1):49–68. doi: 10.1289/ehp.01109s149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DeKoning E. P., Karmaus W. PCB exposure in utero and via breast milk. A review. J Expo Anal Environ Epidemiol. 2000 May-Jun;10(3):285–293. doi: 10.1038/sj.jea.7500090. [DOI] [PubMed] [Google Scholar]
- Dewailly E., Ryan J. J., Laliberté C., Bruneau S., Weber J. P., Gingras S., Carrier G. Exposure of remote maritime populations to coplanar PCBs. Environ Health Perspect. 1994 Jan;102 (Suppl 1):205–209. doi: 10.1289/ehp.94102s1205. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ejobi F., Kanja L. W., Kyule M. N., Müller P., Krüger J., Latigo A. A. Organochlorine pesticide residues in mothers' milk in Uganda. Bull Environ Contam Toxicol. 1996 Jun;56(6):873–880. doi: 10.1007/s001289900127. [DOI] [PubMed] [Google Scholar]
- Eriksson P., Jakobsson E., Fredriksson A. Brominated flame retardants: a novel class of developmental neurotoxicants in our environment? Environ Health Perspect. 2001 Sep;109(9):903–908. doi: 10.1289/ehp.01109903. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Falk C., Hanrahan L., Anderson H. A., Kanarek M. S., Draheim L., Needham L., Patterson D., Jr Body burden levels of dioxin, furans, and PCBs among frequent consumers of Great Lakes sport fish. The Great Lakes Consortium. Environ Res. 1999 Feb;80(2 Pt 2):S19–S25. doi: 10.1006/enrs.1998.3906. [DOI] [PubMed] [Google Scholar]
- Fisher J., Mahle D., Bankston L., Greene R., Gearhart J. Lactational transfer of volatile chemicals in breast milk. Am Ind Hyg Assoc J. 1997 Jun;58(6):425–431. doi: 10.1080/15428119791012667. [DOI] [PubMed] [Google Scholar]
- Fürst P., Fürst C., Wilmers K. Human milk as a bioindicator for body burden of PCDDs, PCDFs, organochlorine pesticides, and PCBs. Environ Health Perspect. 1994 Jan;102 (Suppl 1):187–193. doi: 10.1289/ehp.102-1566908. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gladen B. C., Rogan W. J. DDE and shortened duration of lactation in a northern Mexican town. Am J Public Health. 1995 Apr;85(4):504–508. doi: 10.2105/ajph.85.4.504. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gocmen A., Peters H. A., Cripps D. J., Bryan G. T., Morris C. R. Hexachlorobenzene episode in Turkey. Biomed Environ Sci. 1989 Mar;2(1):36–43. [PubMed] [Google Scholar]
- Golding J. Unnatural constituents of breast milk--medication, lifestyle, pollutants, viruses. Early Hum Dev. 1997 Oct 29;49 (Suppl):S29–S43. doi: 10.1016/s0378-3782(97)00052-2. [DOI] [PubMed] [Google Scholar]
- Grandjean P., Jørgensen P. J., Weihe P. Human milk as a source of methylmercury exposure in infants. Environ Health Perspect. 1994 Jan;102(1):74–77. doi: 10.1289/ehp.9410274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gulson B. L., Mahaffey K. R., Jameson C. W., Mizon K. J., Korsch M. J., Cameron M. A., Eisman J. A. Mobilization of lead from the skeleton during the postnatal period is larger than during pregnancy. J Lab Clin Med. 1998 Apr;131(4):324–329. doi: 10.1016/s0022-2143(98)90182-2. [DOI] [PubMed] [Google Scholar]
- Haddow J. E., Palomaki G. E., Allan W. C., Williams J. R., Knight G. J., Gagnon J., O'Heir C. E., Mitchell M. L., Hermos R. J., Waisbren S. E. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med. 1999 Aug 19;341(8):549–555. doi: 10.1056/NEJM199908193410801. [DOI] [PubMed] [Google Scholar]
- Hooper K. Breast Milk Monitoring Programs (BMMPs): world-wide early warning system for polyhalogenated POPs and for targeting studies in children's environmental health. Environ Health Perspect. 1999 Jun;107(6):429–430. doi: 10.1289/ehp.107-1566564. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hooper K., Chuvakova T., Kazbekova G., Hayward D., Tulenova A., Petreas M. X., Wade T. J., Benedict K., Cheng Y. Y., Grassman J. Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakhstan: sources of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposures in an agricultural region of southern Kazakhstan. Environ Health Perspect. 1999 Jun;107(6):447–457. doi: 10.1289/ehp.99107447. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hooper K., McDonald T. A. The PBDEs: an emerging environmental challenge and another reason for breast-milk monitoring programs. Environ Health Perspect. 2000 May;108(5):387–392. doi: 10.1289/ehp.00108387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hooper K., Petreas M. X., Chuvakova T., Kazbekova G., Druz N., Seminova G., Sharmanov T., Hayward D., She J., Visita P. Analysis of breast milk to assess exposure to chlorinated contaminants in Kazakstan: high levels of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in agricultural villages of southern Kazakstan. Environ Health Perspect. 1998 Dec;106(12):797–806. doi: 10.1289/ehp.98106797. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Huisman M., Koopman-Esseboom C., Lanting C. I., van der Paauw C. G., Tuinstra L. G., Fidler V., Weisglas-Kuperus N., Sauer P. J., Boersma E. R., Touwen B. C. Neurological condition in 18-month-old children perinatally exposed to polychlorinated biphenyls and dioxins. Early Hum Dev. 1995 Oct 2;43(2):165–176. doi: 10.1016/0378-3782(95)01674-0. [DOI] [PubMed] [Google Scholar]
- Ip H. M., Phillips D. J. Organochlorine chemicals in human breast milk in Hong Kong. Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):490–494. doi: 10.1007/BF01055014. [DOI] [PubMed] [Google Scholar]
- Jacobson J. L., Jacobson S. W. Intellectual impairment in children exposed to polychlorinated biphenyls in utero. N Engl J Med. 1996 Sep 12;335(11):783–789. doi: 10.1056/NEJM199609123351104. [DOI] [PubMed] [Google Scholar]
- Johansen H. R., Becher G., Polder A., Skaare J. U. Congener-specific determination of polychlorinated biphenyls and organochlorine pesticides in human milk from Norwegian mothers living in Oslo. J Toxicol Environ Health. 1994 Jun;42(2):157–171. doi: 10.1080/15287399409531870. [DOI] [PubMed] [Google Scholar]
- Kanja L., Skåre J. U., Nafstad I., Maitai C. K., Løkken P. Organochlorine pesticides in human milk from different areas of Kenya 1983-1985. J Toxicol Environ Health. 1986;19(4):449–464. doi: 10.1080/15287398609530944. [DOI] [PubMed] [Google Scholar]
- Käfferlein H. U., Angerer J. Trends in the musk xylene concentrations in plasma samples from the general population from 1992/1993 to 1998 and the relevance of dermal uptake. Int Arch Occup Environ Health. 2001 Sep;74(7):470–476. doi: 10.1007/s004200100257. [DOI] [PubMed] [Google Scholar]
- LaKind J. S., Berlin C. M., Naiman D. Q. Infant exposure to chemicals in breast milk in the United States: what we need to learn from a breast milk monitoring program. Environ Health Perspect. 2001 Jan;109(1):75–88. doi: 10.1289/ehp.0110975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Labrèche F. P., Goldberg M. S. Exposure to organic solvents and breast cancer in women: a hypothesis. Am J Ind Med. 1997 Jul;32(1):1–14. doi: 10.1002/(sici)1097-0274(199707)32:1<1::aid-ajim1>3.0.co;2-3. [DOI] [PubMed] [Google Scholar]
- Lawrence R. A. Breastfeeding: benefits, risks and alternatives. Curr Opin Obstet Gynecol. 2000 Dec;12(6):519–524. doi: 10.1097/00001703-200012000-00011. [DOI] [PubMed] [Google Scholar]
- Longnecker M. P., Rogan W. J., Lucier G. The human health effects of DDT (dichlorodiphenyltrichloroethane) and PCBS (polychlorinated biphenyls) and an overview of organochlorines in public health. Annu Rev Public Health. 1997;18:211–244. doi: 10.1146/annurev.publhealth.18.1.211. [DOI] [PubMed] [Google Scholar]
- Lordo R. A., Dinh K. T., Schwemberger J. G. Semivolatile organic compounds in adipose tissue: estimated averages for the US population and selected subpopulations. Am J Public Health. 1996 Sep;86(9):1253–1259. doi: 10.2105/ajph.86.9.1253. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lundén A., Norén K. Polychlorinated naphthalenes and other organochlorine contaminants in Swedish human milk, 1972-1992. Arch Environ Contam Toxicol. 1998 May;34(4):414–423. doi: 10.1007/s002449900338. [DOI] [PubMed] [Google Scholar]
- Lutter C., Iyengar V., Barnes R., Chuvakova T., Kazbekova G., Sharmanov T. Breast milk contamination in Kazakhstan: implications for infant feeding. Chemosphere. 1998 Oct-Nov;37(9-12):1761–1772. doi: 10.1016/s0045-6535(98)00241-0. [DOI] [PubMed] [Google Scholar]
- López-Carrillo L., Torres-Arreola L., Torres-Sánchez L., Espinosa-Torres F., Jiménez C., Cebrián M., Waliszewski S., Saldate O. Is DDT use a public health problem in Mexico? Environ Health Perspect. 1996 Jun;104(6):584–588. doi: 10.1289/ehp.104-1469381. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meironyté D., Norén K., Bergman A. Analysis of polybrominated diphenyl ethers in Swedish human milk. A time-related trend study, 1972-1997. J Toxicol Environ Health A. 1999 Nov 26;58(6):329–341. doi: 10.1080/009841099157197. [DOI] [PubMed] [Google Scholar]
- Mes J., Davies D. J. Presence of polychlorinated biphenyl and organochlorine pesticide residues and the absence of polychlorinated terphenyls in Canadian human milk samples. Bull Environ Contam Toxicol. 1979 Feb;21(3):381–387. doi: 10.1007/BF01685440. [DOI] [PubMed] [Google Scholar]
- Mes J., Davies D. J., Turton D., Sun W. F. Levels and trends of chlorinated hydrocarbon contaminants in the breast milk of Canadian women. Food Addit Contam. 1986 Oct-Dec;3(4):313–322. doi: 10.1080/02652038609373598. [DOI] [PubMed] [Google Scholar]
- Moline J., Lopez Carrillo L., Torres Sanchez L., Godbold J., Todd A. Lactation and lead body burden turnover: a pilot study in Mexico. J Occup Environ Med. 2000 Nov;42(11):1070–1075. doi: 10.1097/00043764-200011000-00007. [DOI] [PubMed] [Google Scholar]
- Norén K. Contemporary and retrospective investigations of human milk in the trend studies of organochlorine contaminants in Sweden. Sci Total Environ. 1993 Nov 1;139-140:347–355. doi: 10.1016/0048-9697(93)90032-2. [DOI] [PubMed] [Google Scholar]
- Norén K., Meironyté D. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemosphere. 2000 May-Jun;40(9-11):1111–1123. doi: 10.1016/s0045-6535(99)00360-4. [DOI] [PubMed] [Google Scholar]
- Oddy W. H. Breastfeeding protects against illness and infection in infants and children: a review of the evidence. Breastfeed Rev. 2001 Jul;9(2):11–18. [PubMed] [Google Scholar]
- Oskarsson A., Palminger Hallén I., Sundberg J. Exposure to toxic elements via breast milk. Analyst. 1995 Mar;120(3):765–770. doi: 10.1039/an9952000765. [DOI] [PubMed] [Google Scholar]
- Oskarsson A., Palminger Hallén I., Sundberg J., Petersson Grawé K. Risk assessment in relation to neonatal metal exposure. Analyst. 1998 Jan;123(1):19–23. doi: 10.1039/a705136k. [DOI] [PubMed] [Google Scholar]
- Oskarsson A., Schültz A., Skerfving S., Hallén I. P., Ohlin B., Lagerkvist B. J. Total and inorganic mercury in breast milk in relation to fish consumption and amalgam in lactating women. Arch Environ Health. 1996 May-Jun;51(3):234–241. doi: 10.1080/00039896.1996.9936021. [DOI] [PubMed] [Google Scholar]
- Ott M., Failing K., Lang U., Schubring C., Gent H. J., Georgii S., Brunn H. Contamination of human milk in Middle Hesse, Germany--a cross-sectional study on the changing levels of chlorinated pesticides, PCB congeners and recent levels of nitro musks. Chemosphere. 1999 Jan;38(1):13–32. doi: 10.1016/s0045-6535(98)00165-9. [DOI] [PubMed] [Google Scholar]
- Pardío V. T., Waliszewski S. M., Aguirre A. A., Coronel H., Burelo G. V., Infanzon R R. M., Rivera J. DDT and its metabolites in human milk collected in Veracruz City and suburban areas (Mexico). Bull Environ Contam Toxicol. 1998 Jun;60(6):852–857. doi: 10.1007/s001289900705. [DOI] [PubMed] [Google Scholar]
- Pellizzari E. D., Hartwell T. D., Harris B. S., 3rd, Waddell R. D., Whitaker D. A., Erickson M. D. Purgeable organic compounds in mother's milk. Bull Environ Contam Toxicol. 1982 Mar;28(3):322–328. doi: 10.1007/BF01608515. [DOI] [PubMed] [Google Scholar]
- Peters H. A., Gocmen A., Cripps D. J., Bryan G. T., Dogramaci I. Epidemiology of hexachlorobenzene-induced porphyria in Turkey: clinical and laboratory follow-up after 25 years. Arch Neurol. 1982 Dec;39(12):744–749. doi: 10.1001/archneur.1982.00510240006002. [DOI] [PubMed] [Google Scholar]
- Polder A., Becher G., Savinova T. N., Skaare J. U. Dioxins, PCBs and some chlorinated pesticides in human milk from the Kola Peninsula, Russia. Chemosphere. 1998 Oct-Nov;37(9-12):1795–1806. doi: 10.1016/s0045-6535(98)00245-8. [DOI] [PubMed] [Google Scholar]
- Polishuk Z. W., Ron M., Wassermann M., Cucos S., Wassermann D., Lemesch C. Organochlorine compounds in human blood plasma and milk. Pestic Monit J. 1977 Mar;10(4):121–129. [PubMed] [Google Scholar]
- Prachar V., Veningerová M., Uhnák J. Levels of polychlorinated biphenyls and some other organochlorine compounds in breast milk samples in Bratislava. Sci Total Environ. 1993;Suppl Pt 1:237–242. doi: 10.1016/s0048-9697(05)80024-5. [DOI] [PubMed] [Google Scholar]
- Rabinowitz M., Leviton A., Needleman H. Lead in milk and infant blood: a dose-response model. Arch Environ Health. 1985 Sep-Oct;40(5):283–286. doi: 10.1080/00039896.1985.10545933. [DOI] [PubMed] [Google Scholar]
- Radisch B., Luck W., Nau H. Cadmium concentrations in milk and blood of smoking mothers. Toxicol Lett. 1987 Apr;36(2):147–152. doi: 10.1016/0378-4274(87)90178-0. [DOI] [PubMed] [Google Scholar]
- Rogan W. J., Bagniewska A., Damstra T. Pollutants in breast milk. N Engl J Med. 1980 Jun 26;302(26):1450–1453. doi: 10.1056/NEJM198006263022604. [DOI] [PubMed] [Google Scholar]
- Savage E. P., Keefe T. J., Tessari J. D., Wheeler H. W., Applehans F. M., Goes E. A., Ford S. A. National study of chlorinated hydrocarbon insecticide residues in human milk, USA. I. Geographic distribution of dieldrin, heptachlor, heptachlor epoxide, chlordane, oxychlordane, and mirex. Am J Epidemiol. 1981 Apr;113(4):413–422. doi: 10.1093/oxfordjournals.aje.a113109. [DOI] [PubMed] [Google Scholar]
- Schade G., Heinzow B. Organochlorine pesticides and polychlorinated biphenyls in human milk of mothers living in northern Germany: current extent of contamination, time trend from 1986 to 1997 and factors that influence the levels of contamination. Sci Total Environ. 1998 Apr 23;215(1-2):31–39. doi: 10.1016/s0048-9697(98)00008-4. [DOI] [PubMed] [Google Scholar]
- Schlumpf M., Cotton B., Conscience M., Haller V., Steinmann B., Lichtensteiger W. In vitro and in vivo estrogenicity of UV screens. Environ Health Perspect. 2001 Mar;109(3):239–244. doi: 10.1289/ehp.01109239. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schoula R., Hajslová J., Bencko V., Poustka J., Holadová K., Vízek V. Occurrence of persistent organochlorine contaminants in human milk collected in several regions of Czech Republic. Chemosphere. 1996 Oct;33(8):1485–1494. doi: 10.1016/0045-6535(96)00287-1. [DOI] [PubMed] [Google Scholar]
- Schreiber J. S. Predicted infant exposure to tetrachloroethene in human breastmilk. Risk Anal. 1993 Oct;13(5):515–524. doi: 10.1111/j.1539-6924.1993.tb00010.x. [DOI] [PubMed] [Google Scholar]
- Sim M. R., McNeil J. J. Monitoring chemical exposure using breast milk: a methodological review. Am J Epidemiol. 1992 Jul 1;136(1):1–11. doi: 10.1093/oxfordjournals.aje.a116412. [DOI] [PubMed] [Google Scholar]
- Skaare J. U., Tuveng J. M., Sande H. A. Organochlorine pesticides and polychlorinated biphenyls in maternal adipose tissue, blood, milk, and cord blood from mothers and their infants living in Norway. Arch Environ Contam Toxicol. 1988 Jan;17(1):55–63. doi: 10.1007/BF01055154. [DOI] [PubMed] [Google Scholar]
- Smith D. Worldwide trends in DDT levels in human breast milk. Int J Epidemiol. 1999 Apr;28(2):179–188. doi: 10.1093/ije/28.2.179. [DOI] [PubMed] [Google Scholar]
- Somogyi A., Beck H. Nurturing and breast-feeding: exposure to chemicals in breast milk. Environ Health Perspect. 1993 Jul;101 (Suppl 2):45–52. doi: 10.1289/ehp.93101s245. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Sonawane B. R. Chemical contaminants in human milk: an overview. Environ Health Perspect. 1995 Sep;103 (Suppl 6):197–205. doi: 10.1289/ehp.95103s6197. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stacey C. I., Tatum T. House treatment with organochlorine pesticides and their levels in human milk--Perth, Western Australia. Bull Environ Contam Toxicol. 1985 Aug;35(2):202–208. doi: 10.1007/BF01636499. [DOI] [PubMed] [Google Scholar]
- Taguchi S., Yakushiji T. Influence of termite treatment in the home on the chlordane concentration in human milk. Arch Environ Contam Toxicol. 1988 Jan;17(1):65–71. doi: 10.1007/BF01055155. [DOI] [PubMed] [Google Scholar]
- Tilson H. A., Kodavanti P. R. Neurochemical effects of polychlorinated biphenyls: an overview and identification of research needs. Neurotoxicology. 1997;18(3):727–743. [PubMed] [Google Scholar]
- Vartiainen T., Saarikoski S., Jaakkola J. J., Tuomisto J. PCDD, PCDF, and PCB concentrations in human milk from two areas in Finland. Chemosphere. 1997 Jun;34(12):2571–2583. doi: 10.1016/s0045-6535(97)00100-8. [DOI] [PubMed] [Google Scholar]
- Waliszewski S. M., Pardio Sedas V. T., Chantiri J. N., Infanzon R. M., Rivera J. Organochlorine pesticide residues in human breast milk from tropical areas in Mexico. Bull Environ Contam Toxicol. 1996 Jul;57(1):22–28. doi: 10.1007/s001289900150. [DOI] [PubMed] [Google Scholar]
- Wickström K., Pyysalo H., Siimes M. A. Levels of chlordane, hexachlorobenzene, PCB and DDT compounds in Finnish human milk in 1982. Bull Environ Contam Toxicol. 1983 Sep;31(3):251–256. doi: 10.1007/BF01608694. [DOI] [PubMed] [Google Scholar]
- Winter M., Thomas M., Wernick S., Levin S., Farvar M. T. Analysis of pesticide residues in 290 samples of Guatemalan mother's milk. Bull Environ Contam Toxicol. 1976 Dec;16(6):652–657. doi: 10.1007/BF01685569. [DOI] [PubMed] [Google Scholar]
- Wolff M. S. Occupationally derived chemicals in breast milk. Am J Ind Med. 1983;4(1-2):259–281. [PubMed] [Google Scholar]
- Yakushiji T., Watanabe I., Kuwabara K., Yoshida S., Koyama K., Kunita N. Levels of polychlorinated biphenyls (PCBs) and organochlorine pesticides in human milk and blood collected in Osaka Prefecture from 1972 to 1977. Int Arch Occup Environ Health. 1979 Mar 7;43(1):1–15. doi: 10.1007/BF00454276. [DOI] [PubMed] [Google Scholar]
- de Campos M., Olszyna-Marzys A. E. Contamination of human milk with chlorinated pesticides in Guatemala and in El Salvador. Arch Environ Contam Toxicol. 1979;8(1):43–58. doi: 10.1007/BF01055139. [DOI] [PubMed] [Google Scholar]