Table 3.
Number of Episodes of Sustained Deviations Per 24 h
| Intention-to-treat population | ||
|---|---|---|
| Intervention (n = 200) |
Control (n = 200) |
|
| n (%) | n (%) | |
| Desaturation | ||
| Spo2 < 92% for ≥60 min | 105 (53) | 109 (55) |
| Spo2 < 88% for ≥10 min | 117 (59) | 124 (62) |
| Spo2 < 85% for ≥5 min | 90 (45) | 99 (50) |
| Spo2 < 80% for ≥1 min | 52 (26) | 51 (26) |
| Bradypnea | ||
| RF ≤ 5 min–1 for >1 min | 4 (2.0) | 7 (3.5) |
| RF < 11 min–1 for ≥5 min | 16 (8.0) | 17 (8.5) |
| Tachypnea | ||
| RF ≥ 24 min–1 for ≥5 min | 54 (27) | 70 (35) |
| Bradycardia | ||
| HR < 30 min–1 for ≥1 min | 1 (0.5) | 6 (3.0) |
| HR [30–39] min–1 for ≥5 min | 2 (1.0) | 7 (3.5) |
| Tachycardia | ||
| HR ≥ 111 min–1 for ≥60 min | 12 (6.0) | 15 (7.5) |
| HR > 130 min–1 for ≥30 min | 5 (2.5) | 6 (3.0) |
| Hypotension | ||
| SBP <70 mm Hg for >30 min | 10 (5.0) | 11 (5.5) |
| SBP <91 mm Hg for >60 min | 62 (31) | 64 (32) |
| Hypertension | ||
| SBP >180 mm Hg for ≥60 min | 69 (35) | 68 (34) |
| SBP ≥220 mm Hg for >30 min | 9 (4.5) | 12 (6.0) |
| Combined deviations— SBP <100 mm Hg AND |
||
| Spo2 < 92% for >10 min | 47 (24) | 61 (31) |
| HR > 110 min–1 for >30 min | 4 (2.0) | 9 (3.5) |
| HR < 50 min–1 for >30 min | 1 (0.5) | 5 (2.5) |
| Any episode | 185 (93) | 189 (95) |
Episodes of Spo2 < 92% were not calculated for patients with COPD or BMI ≥40 kg/m2. To trigger an episode of bradypnea ≤5 min–1 a heart rate >20 min–1 was also needed to ensure that critical bradypnea was not a result of sensor disconnection. To trigger an episode of bradypnea <11 min–1 an Spo2 < 88% was also needed to ensure that bradypnea was a symptom of respiratory distress. “Any episode” is the number of patients with at least 1 episode of sustained deviations from any of the above definitions.
Abbreviations: HR, heart rate; RF, respiration frequency; SBP, systolic blood pressure; Spo2, peripheral arterial oxygen saturation.