Skip to main content
. 2025 Aug 21;12:1660872. doi: 10.3389/fvets.2025.1660872

Table 2.

Summary of all metabolites of APM in vitro and in vivoa.

ID Description Formula [M + H]+ Observed m/z Retention time (min) Mass error (mDa) Mass error (ppm) Major fragments In vitro-microsome In vivo-rat In vivo-chicken
Human Rat Pig Chicken Dog Plasma Urine Feces Plasma Feces
M0 APM C28H39NO4S+ 486.2675 13.7 0.2 0.5 184.04, 303.23, 285.22, 124.02, 267.21, 166.03 + + + + + + + + + +
M1 APM + O C28H39NO5S+ 502.2624 9.1 0.3 0.5 109.05, 200.04, 140.02, 303.23 + + + + + + + + + +
M2 APM-Sulfoxide C28H39NO5S+ 502.2620 11.9 −0.2 −0.3 200.04, 182.04, 140.02, 303.23, + + + + + + ND + + +
M3 APM + O C28H39NO5S+ 502.2644 10.0 2.3 4.5 184.04, 166.03, 301.22 + + ND ND + ND ND ND ND ND
M4 APM + O C28H39NO5S+ 502.2607 10.6 −1.5 −2.9 184.04, 166.03, 319.23, 301.22 + + + + + ND + ND ND +
M5 APM + O C28H39NO5S+ 502.2625 11.3 0.3 0.7 184.04, 124.02, 166.03, 301.22 + + + + + + + + + +
M6 APM + O C28H39NO5S+ 502.2640 12.7 1.8 3.6 184.04, 301.22, 337.24 ND + ND ND + ND ND ND ND ND
M7 APM + 2O C28H39NO6S+ 518.2575 6.1 0.4 0.8 200.04, 109.05, 319.23, 140.02 + + + ND + ND + + + +
M8 APM + 2O C28H39NO6S+ 518.2582 6.9 1.1 2.1 200.04, 319.23, 109.05, 140.02 + ND + ND ND + + + + +
M9 APM-Sulfoxide + O C28H39NO6S+ 518.2582 7.3 1.1 2.2 200.04, 301.22, 353.25 ND ND ND ND ND ND ND + + +
M10 APM-Sulfoxide + O C28H39NO6S+ 518.2577 8.1 0.7 1.3 200.04, 182.03, 140.02, 301.22 + + + ND + ND + ND ND ND
M11 APM-Sulfoxide + O C28H39NO6S+ 518.2574 8.6 0.3 0.7 200.04, 301.22, 162.91 + + + ND ND ND ND ND ND ND
M12 APM-Sulfoxide + O C28H39NO6S+ 518.2571 8.9 0.0 0.0 200.04, 182.03, 140.02, 301.22 + + + + + ND + + + +
M13 APM-Sulfoxide + O C28H39NO6S+ 518.2575 9.7 0.4 0.8 200.04, 182.03, 140.02, 319.23 + ND + + ND + + + + +
M14 APM-Sulfoxide + O C28H39NO6S+ 518.2576 10.0 0.6 1.1 200.04, 182.03, 140.02, 301.22 + ND + + ND ND + + + +
M15 APM + 2O C28H39NO6S+ 518.2558 9.5 −1.3 −2.5 184.04, 166.07, 317.21, 299.20 ND + ND ND + ND + ND ND ND
M16 APM + 2O C28H39NO6S+ 518.2573 10.3 0.3 0.6 184.04, 335.22, 299.20, 155.1 + + + ND + ND + ND ND ND
M17 APM-sulfoxide + 2O C28H39NO7S+ 534.2527 5.4 0.7 1.3 200.04, 317.21, 140.02, 295.09 + + + ND ND ND + + ND +
M18 APM-sulfoxide + 2O C28H39NO7S+ 534.2532 5.7 1.2 2.3 200.04, 335.22, 317.21, 299.20 ND ND ND ND ND ND ND + + +
M19 APM-sulfoxide + 2O C28H39NO7S+ 534.2509 7.2 −1.0 −1.9 182.03, 200.04, 317.21, 395.24 ND ND ND ND ND ND + ND ND +
M20 APM-sulfoxide + 2O C28H39NO7S+ 534.2523 8.1 0.3 0.7 200.04, 317.21, 182.03 + + + ND ND ND ND + ND +
M21 APM-sulfoxide + 2O C28H39NO7S+ 534.2517 7.7 −0.3 −0.5 200.04, 317.21, 166.03, 299.13 ND ND ND ND ND ND + + ND +
M22 APM + 3O C28H39NO7S+ 534.2520 8.5 0.0 0.1 184.04, 299.13, 333.21 ND ND ND ND ND ND + + ND +
M23 APM + 3O C28H39NO7S+ 534.2540 9.5 2.1 3.9 184.04, 333.21, 315.20, 180.10 ND ND ND ND ND ND ND + ND ND
M24 APM-sulfone + O C28H39NO7S+ 534.2522 10.2 0.2 0.4 109.05, 232.02, 303.23, 285.22 + ND ND ND ND ND ND + + +
M25 APM-sulfone + O C28H39NO7S+ 534.2509 10.9 −0.1 −0.2 109.05, 232.02, 303.23, 267.21 ND ND ND ND ND ND ND + ND ND
M26 APM-sulfoxide + 3O C28H39NO8S+ 550.2467 7.5 −0.2 −0.4 351.24, 200.04, 315.20, 331.08 ND ND ND ND ND ND ND + ND ND
M27 APM-sulfone + 2O C28H39NO8S+ 550.2474 8.0 0.5 0.9 109.05, 232.02, 301.22, 319.23 ND ND ND ND ND ND ND + ND ND

+, detected; ND, undetected.