Table 2. Univariable and multivariable Cox regression analysis for the composite endpoint of all-cause mortality and aortic valve replacement.
| Univariable analysis | Multivariable analysis | |||
|---|---|---|---|---|
| Variable | HR (95% CI) | P value | HR (95% CI) | P value |
| Age, per 5 years* | 1.22 (1.15 to 1.30) | <0.001 | 1.26 (1.18 to 1.34) | <0.001 |
| Sex, female | 1.19 (0.96 to 1.48) | 0.12 | ||
| Turner syndrome | 1.04 (0.56 to 1.95) | 0.90 | ||
| History of hypertension* | 2.01 (1.59 to 2.54) | <0.001 | ||
| History of coarctation | 1.07 (0.77 to 1.50) | 0.68 | ||
| NYHA≥2* | 2.09 (1.19 to 3.68) | 0.01 | ||
| Prior AV intervention* | 0.78 (0.68 to 0.90) | <0.001 | ||
| SBP, per 5 mm Hg | 1.02 (0.97 to 1.07) | 0.36 | ||
| DBP, per 5 mm Hg* | 1.09 (1.01 to 1.17) | 0.03 | ||
| AV peak velocity, m/s* | 2.88 (2.21 to 3.76) | <0.001 | 3.17 (2.29 to 4.39) | <0.001 |
| AR, moderate | 0.89 (0.60 to 1.33) | 0.56 | ||
| Impaired LV systolic function | 1.43 (0.84 to 2.44) | 0.19 | ||
| LVEDD, mm* | 0.96 (0.94 to 0.99) | 0.006 | ||
| LVESD, mm | 0.98 (0.96 to 1.00) | 0.047 | ||
| LV concentric geometry* | 2.75 (1.91 to 3.96) | <0.001 | 1.64 (1.04 to 2.58) | 0.03 |
| Non-sinus rhythm* | 2.15 (1.27 to 3.67) | 0.005 | 3.12 (1.62 to 6.02) | 0.002 |
| Heart rate, bpm | 1.01 (1.00 to 1.02) | 0.19 | ||
| PR-interval, ms * | 1.01 (1.00 to 1.02) | 0.01 | 1.00 (1.00 to 1.01) | 0.07 |
| QRS duration, ms | 1.00 (1.00 to 1.01) | 0.32 | ||
*
Included in full model for backward selection in multivariable analysis.
AV, aortic valve; AR, aortic regurgitation; DBP, diastolic blood pressure; LV, left ventricle; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; NYHA, New York Heart Association; SBP, systolic blood pressure.