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. 2025 Aug 22;16:1629434. doi: 10.3389/fneur.2025.1629434

Table 2.

Multivariable regression analysis to predict poor 90-day clinical outcome (mRS 3–6) with ASPECTS-based model and NWU-based model.

Variable Odds ratio 95% Confidence interval p-value
ASPECTS-based Model
Age (years) 1.02 [1.00, 1.03] 0.017
NIHSS on arrival 1.10 [1.06, 1.14] <0.001
Received IV tPA 0.48 [0.31, 0.76] 0.002
Received Endovascular Therapy 0.71 [0.42, 1.21] 0.21
ASPECTS 0.84 [0.74, 0.95] 0.008
NWU-based Model
Age (years) 1.02 [1.00, 1.03] 0.046
NIHSS on arrival 1.11 [1.07, 1.15] <0.001
Received IV tPA 0.50 [0.31, 0.78] 0.003
Received Endovascular Therapy 0.79 [0.46, 1.33] 0.37
Average NWU 1.14 [1.02, 1.26] 0.019

ASPECTS, Alberta Stroke Program Early CT Score, NIHSS, National Institutes of Health Stroke Scale, tPA, tissue plasminogen activator, NWU, net water uptake. All analyses were performed in the R statistical software.