Table 4. Multivariate logistic regression analysis table showing independent risk factors associated with ICP development in the study population.
|
Outcome: ICP (group: all, n=198) | |||
|
Independent risk factors |
OR |
95% CI |
p-value* |
|
First trimester AST (IU/L) |
0.84 |
0.78-0.90 |
<0.001 |
|
First trimester ALT (IU/L) |
1.16 |
1.09-1.24 |
<0.001 |
|
TACPR >1 at first trimester |
5.49 |
2.48-12.18 |
<0.001 |
ALT: Alanine transaminase, AST: Aspartate transaminase, CI: Confidence interval, ICP: Intrahepatic cholestasis of pregnancy, OR: Odds ratio, TACPR: Transaminase complex-to-platelet ratio. Nagelkerke R²=0.426; Hosmer and Lemeshow test: χ²=8.606; df=8; p=0.377.
*Significance threshold: p<0.05