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. 2002 Dec;110(Suppl 6):919–923. doi: 10.1289/ehp.02110s6919

Application of genomics to toxicology research.

Russell S Thomas 1, David R Rank 1, Sharron G Penn 1, Gina M Zastrow 1, Kevin R Hayes 1, Tianhua Hu 1, Kalyan Pande 1, Mark Lewis 1, Stevan B Jovanovich 1, Christopher A Bradfield 1
PMCID: PMC1241273  PMID: 12634120

Abstract

Traditional models of toxicity have relied on dissecting chemical action into pharmacokinetic and pharmacodynamic processes. However, the integration of genomic information with toxicology will enhance our basic understanding of these processes and significantly change the way we apply toxicological information to risk assessment and regulatory problems. In this article, we summarize the application of gene expression information and polymorphism discovery to four areas in toxicology: toxicity testing, cross-species extrapolation, understanding mechanism of action, and susceptibility.

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Selected References

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