Table 1.
SCD-Well sample baseline characteristics (participants with ≥ 1 NfL value available).
| Trial arm |
||
|---|---|---|
| Variable | HSMP (n = 67) | CMBAS (n = 70) |
| Site | ||
| Barcelona | 20 (30 %) | 20 (28 %) |
| Cologne | 19 (28 %) | 18 (26 %) |
| London | 14 (21 %) | 14 (20 %) |
| Lyon | 14 (21 %) | 18 (26 %) |
| Sex (female) | 41 (61 %) | 44 (63 %) |
| Ethnicity | ||
| Asian | 1 (2 %) | 1 (1 %) |
| White | 66 (98 %) | 66 (95 %) |
| Mixed | 0 (0 %) | 2 (3 %) |
| Other | 0 (0 %) | 1 (1 %) |
| Age (years) | 73.3 (5.9) | 72.1 (7.6) |
| Education (years) | 13.3 (3.5) | 13.9 (3.8) |
| NfL (pg/ml) | ||
| Untransformed | 26.7 (15.3) | 24.1 (12.7) |
| Log-transformed | 3.1 (0.7) | 3.1 (0.5) |
| Aβ42/Aβ40 (pg/ml) | 0.06 (0.04) | 0.06 (0.01) |
| P-tau-181 (pg/ml) | 1.8 (1.1) | 1.7 (0.9) |
| PASE (global score; range 0–400) | 117.5 (65.2) | 132.0 (75.5) |
| DRS-2 (global score; range 0–144) | 139.3 (3.5) | 140.2 (3.8) |
| Trait-STAI (range 20–80) | 38.6 (9.4) | 41.0 (10.2) |
| BMI (kg/m2) | 26.0 (4.3) | 26.1 (3.7) |
| Renal insufficiency (yes) | 1 (1 %) | 6 (9 %) |
| APOE (ε4 carrier) | 19 (31 %) | 21 (30 %) |
Data shown as n ( %) or mean (SD). BMI = body mass index. CMBAS = caring mindfulness-based approach for seniors. DRS-2 = Mattis dementia rating scale-2. HSMP = health self-management program. NfL = neurofilament light. PASE = physical activity scale for the elderly. Trait-STAI = state-trait anxiety inventory (trait subscale). APOE = apolipoprotein E gene. Aβ = amyloid-beta peptide. P-tau-181 = tau phosphorylated at threonine 181. In the HSMP arm, there were missing data in baseline NfL (n = 1), P-tau-181 (n = 1), PASE (n = 3) and APOE (n = 5). In the CMBAS arm, there were missing data in P-tau-181 (n = 1), PASE (n = 2), DRS-2 (n = 1), trait-STAI (n = 1) and APOE (n = 1).