Figure 2.

Distribution of GWAS hits across the genome and disease group enrichment

(A) Distribution of fine-mapped GWAS hits throughout the genome across 1,035 FinnGen diseases, binned into 100-kb bins.

(B) Enrichment of association signal in the HLA region by disease group. The 1,035 diseases were categorized into 45 disease groups based on ICD codes, and the average per-SNP enrichment in the HLA region was calculated by comparing the number of independent associations in the HLA region relative to that in the rest of the genome.

(C) Classification of diseases with at least one significant SNP association in the HLA region by shared pathophysiology.