Figure 5.

Haplotype group regression results

A dendrogram showing the clustering of the 40 most frequent haplotypes per haplotype group, with white representing the reference allele and black representing the effect allele. Genes are labeled below the corresponding SNPs overlapping their genome position, indicating which are within gene boundaries and which are intergenic. Heatmap showing the Z scores from the haplotype group regression analysis across associated diseases for (A) block 1, (B) block 2, and (C) block 3, including all diseases with at least one association $|$Z$|$ > 4 in that block, and all haplotype groups with at least one disease association or total copies greater than the minimum cutoff of 20,000 copies. For visualization purposes, diseases are clustered, and Z scores were set to a maximum $|$Z$|$ of 5. MS, multiple sclerosis; CTDs, connective tissue diseases; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; Rx, medical prescription; T1D, type 1 diabetes; CKD, chronic kidney disease; STD, sexually transmitted disease. See Table S1 for the full description of all diseases.