Table 2. Box–Behnken Design and the experimental data .
|
Factor 1 |
Factor 2 |
Factor 3 |
Response 1 |
Response 2 |
Response 3 |
|
A: Stabilizer concentration, % |
B: Homogenization speed, rpm |
C: Homogenization time, mins |
PS (Y1), nm |
PdI (Y2) |
EE % (Y3) |
|
1.5 |
15000 |
5 |
207.12 |
0.332 |
52.26 |
|
1 |
12500 |
5 |
302.88 |
0.416 |
70.03 |
|
2 |
12500 |
15 |
234.4 |
0.229 |
78.16 |
|
2 |
12500 |
5 |
244.12 |
0.262 |
61.9 |
|
1 |
12500 |
15 |
296 |
0.488 |
73.25 |
|
1.5 |
10000 |
5 |
302.03 |
0.32 |
71.94 |
|
2 |
10000 |
10 |
197.89 |
0.229 |
65.16 |
|
1.5 |
12500 |
10 |
182.78 |
0.182 |
66.44 |
|
2 |
15000 |
10 |
199.64 |
0.132 |
64.04 |
|
1.5 |
12500 |
10 |
209.26 |
0.234 |
66 |
|
1.5 |
12500 |
10 |
209.1 |
0.229 |
64.77 |
|
1.5 |
12500 |
10 |
204.7 |
0.244 |
64.08 |
|
1.5 |
15000 |
15 |
258.44 |
0.288 |
71.41 |
|
1 |
10000 |
10 |
256.3 |
0.418 |
76.47 |
|
1.5 |
12500 |
10 |
210.5 |
0.183 |
66.1 |
|
1.5 |
10000 |
15 |
199.2 |
0.36 |
68.36 |
|
1 |
15000 |
10 |
254 |
0.336 |
56.66 |
PS: Particle size, PdI: Polydispersity index, EE: Encapsulation efficiency