Table 3.
Serum level of markers related to bone metabolism.
| Parameters | Patients with CKD |
Control | p | |
|---|---|---|---|---|
| CKD-I (n = 56) | CKD-II (n = 38) | |||
| ALP (U/L) | 93.3 ± 56.9 (55)b | 89.1 ± 46.6 (38)b | 67.5 ± 17.3 (48) | 0.002a |
| Ca (mg/dL) | 9.3 ± 1.0 (55) | 9.5 ± 0.6 (38) | 9.4 ± 0.5 (80) | 0.455 |
| P (mg/dL) | 4.4 ± 1.7 (55)b | 3.6 ± 0.7 (37) | 3.5 ± 0.6 (79) | 0.007a |
| PTH Intact ECLIA (pg/mL) | 250.1 ± 205.8 (34)b,c | 68.9 ± 71.5 (28) | 40.2 ± 17.7 (56) | < 0.001a |
| TSH (µlU/m) | 3.9 ± 5.7 (19) | 2.1 ± 1.3 (21) | 2.7 ± 1.3 (40) | 0.263 |
| 25(OH)D (ng/ml) | 16.8 ± 11.0 (18)b | 25.5 ± 11.9 (15)b | 64.7 ± 22.7 (27) | < 0.001a |
| 1,25(OH)2D (ng/mL) | 46.9 ± 37.9 (3) | 44.7 ± 30.5 (5) | 63.0 ± 22.6 (15) | 0.486 |
ALP: alkaline phosphatase; Ca: calcium; P: phosphorus; PTH Intact ECLIA: intact-parathyroid hormone electrochemiluminescence immunoassay; TSH: thyroid-stimulating hormone; 25(OH)D: 25-hydroxy vitamin D; 1,25(OH)2D: 1,25-dihydroxy vitamin D.
a
Statistically significant difference using Kruskal-Wallis test (p < 0.05).
b
Statistically significant difference (p < 0.05), Mann-Whitney test with Bonferroni post hoc comparison CKD-1 or CKD-II groups compared with the control.
c
Statistically significant difference (p < 0.05), Mann-Whitney test with Bonferroni post hoc comparison CKD-1 compared with the CKD-II group. Values are presented as mean ± standard deviation (numbers of subjects analyzed).