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. 2025 Aug 21;85(2):214–215. doi: 10.5935/0004-2749.20220096

TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence

Genótipo CT do TXNRD2 (rs35934224) e glaucoma primário de ângulo aberto: correspondência

Pathum Sookaromdee 1,✉, Viroj Wiwanitkit 2
PMCID: PMC12416629  PMID: 35416905

Dear Editor,

We would like to share ideas on “TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population(1).” Tenório et al. concluded that “Our data suggest an association between TXNRD2 gene polymorphism (rs35934224) with primary open-angle glaucoma in an admixed Brazilian population(1). We agree TXNRD2 (rs35934224) CT genotype might be associated with primary open-angle glaucoma. The present report can give good data on genetic underlying background of glaucoma. In this study, Tenório et al. focused only a polymorphism.

Environmental confounding factors might be well controlled but there is a chance of effects of other genetic polymorphisms which are reported for association with primary open-angle glaucoma might still exist. Examples of those genetic polymorphisms are CDKN2B-AS1, GSTO1, GSTO2, GSTP1, GPX1OPA1, MFN1, and MFN2 polymorphisms(2-4). Further studies on effects of other polymorphisms are very interesting.

REFERENCES

  • 1.Tenório AL, Lira RPC, Carmo RFD, Galvão Filho RP, Falcão Neto PT, Vaz RT, et al. TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. Arq Bras Oftalmol [Internet] 2021 doi: 10.5935/0004-2749.20220019. [cited Dec 21]:S0004-2749202100500522 2. Available from: SciELO - Brasil - TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population TXNRD2 (rs35934224) CT genotype as possible protective marker for primary open-angle glaucoma in a Brazilian population. [DOI] [PMC free article] [PubMed] [Google Scholar]
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Arq Bras Oftalmol. 2025 Aug 21;85(2):214–215.

Reply to “TXNRD2 (rs35934224) CT genotype and primary open-angle glaucoma: correspondence”

Resposta a “Genótipo CT do TXNRD2 (rs35934224) e glaucoma primário de ângulo aberto: correspondência”

Artur Lins Tenório 1, Rodrigo Pessoa Cavalcanti Lira 1, Rodrigo Feliciano do Carmo 2, Roberto Pedrosa Galvão Filho 3, Pedro Teixeira Falcão Neto 3, Rinalva Tenório Vaz 4, Raul Emidio de Lima 5, André Lins Tenório 6, Luydson Richardson Vasconcelos 5

To the Editor:

We thank Sookaromdee and Wiwanitkit for their interest and comments on our manuscript. The authors have highlighted the importance of further studies to evaluate the effects of other polymorphisms on primary open-angle glaucoma (POAG). As published by Weinreb et al.(1), glaucoma is a multifactorial disease with incompletely understood pathophysiology. Bailey et al.(2) published a genome-wide association study (GWAS) describing 22 POAG-related single nucleotide polymorphisms (SNPs), of which 19 had been previously described. In addition, Bonnemaijer(3) confirmed the relationship of 15 SNPs with glaucoma in the African population.

Although GWAS studies are important to identify new common polymorphisms associated with diseases, this strategy has some limitations(4) that may lead to false-positive results. In addition, most studies were performed in European and North American populations; therefore, it is of fundamental importance to confirm these polymorphisms in other populations, such as the Brazilian, which has a highly admixed population. Therefore, we decided to verify the association of TXNRD2 (rs35934224) with POAG in a Brazilian population.

As exposed in our work, we also have the conviction that further studies are needed to confirm these associations and try to better understand the disease pathophysiology to be able to propose curative therapies based on these data.

REFERENCES

  • 1.Weinreb RN, Leung CKS, Crowston JG, Medeiros FA, Friedman DS, Wiggs JL, et al. Primary open-angle glaucoma. Nat Rev Dis Primers. 2016;2:16067. doi: 10.1038/nrdp.2016.67. [ [DOI] [PubMed] [Google Scholar]
  • 2.Bailey JN, Loomis SJ, Kang JH, Allingham RR, Gharahkhani P, Khor CC, et al. Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma. Nat Genet [Internet] 2016;48((2)):189–94. doi: 10.1038/ng.3482. [cited 2020 Oct 15] Available from: Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma (nih.gov) [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Bonnemaijer PWM, Iglesias AI, Nadkarni GN, Sanyiwa AJ, Hassan HG, Cook C, GIGA StudyGroup. Simcoe M, Taylor KD, Schurmann C, Belbin GM, Kenny EE, Bottinger EP, van de Laar S, Wiliams SEI, Akafo SK, Ashaye AO, Zangwill LM, Girkin CA, Ng MCY, Rotter JI, Weinreb RN, Li Z, Allingham RR, Eyes of Africa Genetics Consortium. Nag A, Hysi PG, Meester-Smoor MA, Wiggs JL, NEIGHBORHOOD Consortium. Hauser MA, Hammond CJ, Lemij HG, Loos RJF, van Duijn CM, Thiadens AAHJ, Klaver CCW. Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. Hum Genet [Internet] 2018;137((10)):847–62. doi: 10.1007/s00439-018-1943-7. [cited 2019 Mar 19] Available from: Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations (nih.gov) [DOI] [PMC free article] [PubMed] [Google Scholar]

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