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. 2025 Apr 20;48(9):zsaf107. doi: 10.1093/sleep/zsaf107

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Figure 4. — The time of the peak corticosterone response to CRH stimulation in male (left panel) and female (right panel) rats that were chronically sleep restricted (SR) or served as comparison ambulation controls (AC) both with or without a prior history of opioid self-administration (Opioid and Control). Data are expressed as the percentage of animals with peak corticosterone concentrations at 15, 30, or 60 min after CRH stimulation. (a) p < 0.05 for female SR-AC differences in corticosterone peak timing with and without an opioid history. N = 8 per group per sex.