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. 2025 Feb 13;27(7):1888–1898. doi: 10.1093/neuonc/noaf036

Figure 2.

A schematic representation of the three-tier classification of glioma-white matter tract interactions. Type I (Displacement): fiber tracts are displaced by the tumor but remain structurally intact (IDH-negative, MBP-positive). Type II (Infiltration): fiber tracts traverse the tumor-infiltrated region (IDH-positive, MBP-positive). Type III (Disruption): fiber tracts exhibit significant disruption and loss of continuity (IDH-positive, MBP-negative). Immunohistochemical staining results visually validate these classifications.

Schematic representation of white matter fiber tract classification in gliomas. Type Ⅰ, displacement type: fiber tracts are displaced by the tumor but remain structurally intact. Immunohistochemistry: IDH (−), MBP (+). Type Ⅱ, infiltration type: distinct fiber tracts are observed traversing the tumor-infiltrated region. Immunohistochemistry: IDH (+), MBP (+). Type Ⅲ, disruption type: fiber tracts exhibit significant disruption and loss of continuity. Immunohistochemistry: IDH (+), MBP (−).