Table 3.
Model Results
| β | P Value | R2 | BF | |
|---|---|---|---|---|
| Estimated LDL-C exposure | ||||
| NCPVfinal ∼ LDL-Cexp | 0.00 | 0.88 | −0.01 | (01) 9.9 |
| PAVfinal ∼ LDL-Cexp | 0.00 | 0.73 | −0.01 | (01) 9.1 |
| ApoB | ||||
| ΔNCPV ∼ ΔApoB | 0.01 | 0.91 | −0.01 | (01) >10.0 |
| ΔNCPV ∼ ApoB | 0.06 | 0.33 | −0.00 | (01) 6.3 |
| Plaque Metrics | ||||
| ΔNCPV ∼ CACbl | 0.18 | <0.001 | 0.33 | (10) >10.0a |
| ΔNCPV ∼ NCPVbl | 0.25 | <0.001 | 0.49 | (10) >10.0a |
| ΔNCPV ∼ PAVbl | 5.5 | <0.001 | 0.43 | (10) >10.0a |
| ΔNCPV ∼ TPSbl | 7.4 | <0.001 | 0.37 | (10) >10.0a |
| ΔNCPV ∼ CACbl∗ ΔApoB | ||||
| CACbl | 0.18 | <0.001 | 0.33 | N/A |
| ΔApoB | 0.08 | 0.20 | N/A | N/A |
| CACbl: ΔApoB | −0.00 | 0.23 | N/A | N/A |
| Saturated fat | ||||
| ΔNCPV ∼ Saturated fat intake | −0.05 | 0.77 | −0.01 | (01) 9.8 |
| ApoB ∼ Saturated fat intake | −0.03 | 0.90 | −0.01 | (01) >10.0 |
| Age mediation analysis | ||||
| NCPVfinal ∼ Age | 3.0 | 0.004 | 0.07 | (01) 0.3 |
| NCPVfinal ∼ Age + Life-LDL-Cexp | 1.93 | 0.01 | 0.13 | 0.16 | 0.07 | (01) 0.3 | 0.3 |
| NCPVfinal ∼ Age + Life-LDL-Cexp + CACbl | 0.02 | 0.01 | 0.73 | 0.98 | 0.15 | <0.001 | 0.47 | (01) 2.7 | 3.1 | >10.0a |
β = estimate (slope magnitude); ΔNCPV = change in noncalcified plaque volume; ApoB = apolipoprotein B; ApoB = ApoB on a ketogenic diet; ΔApoB = ApoB change during the study; BF = Bayes factor; CACbl = CAC at baseline; LDL-Cexp = LDL-C exposure while on a ketogenic diet (mean 5.7 y); Life-LDL-Cexp = LDL-C exposure over life course to date; NCPVfinal = noncalcified plaque volume at the end of the study; PAV = percent atheroma volume; R2 = squared correlation coefficient (explained variability); TPSfinal = total plaque score at the end of the study; other abbreviations as in Table 1.
a
Models on CAC are provided for the alternative hypothesis (10). All other models are provided for the null hypothesis (01).