Table 2. Prevalence of children with Down syndrome according to birth weight, ethnicity, gender, and preterm birth from 2010 to 2020 by states in Brazil.
| Variables | Children with low-birth weight (up to 2.500 grams) | Children classified as White | Male children | Proportion of preterm births (up to 37 weeks) | ||||
|---|---|---|---|---|---|---|---|---|
| Federative unit (Abbreviation) | Down % | No Down % | Down % | No Down % | Down % | No Down % | Down % | No Down % |
| (CI95%) | (CI95%) | (CI95%) | (CI95%) | (CI95%) | (CI95%) | (CI95%) | (CI95%) | |
| p-value | p-value | p-value | p-value | |||||
| North Region | ||||||||
| Rondônia (RO) | 20.68 | 6.82 | 15.51 | 24.30 | 39.65 | 51.33 | 8.62 | 8.95 |
| (9.68–31.7) | (0.00–13.67) | (5.68–25.36) | (12.64–35.96) | ( 26.36–52.96 ) | ( 37.75–64.93 ) | ( 0.99–16.25 ) | ( 1.19–16.71 ) | |
| p <0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Acre (AC) | 23.33 | 7.51 | 6.67 | 7.37 | 45 | 51.45 | 33.33 | 12.12 |
| (0.0–52.3) | (1.9–10.8) | (73.9–100.0) | (78.9–97.9) | (0.0–100.0) | (49.1–56.4) | (0.0–100.0) | (7.2–17.2) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Amazonas (AM) | 17.98 | 7.5 | 8.99 | 6.33 | 43.82 | 51.21 | 17.98 | 11.05 |
| (5.66–41) | (0.00–18.54) | (0.00–17.1) | (0.00–18.29) | ( 24.21–65.79 ) | ( 30.57–72.33 ) | ( 13.63–53.03 ) | ( 0.00–25.76 ) | |
| p >0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Roraima (RR) | 20.59 | 8.18 | 5.88 | 7.98 | 41.18 | 51.4 | 8.82 | 13.65 |
| (0.13–41.05) | (0.00–22.05) | (0.00–17.79) | (0.00–21.69) | ( 16.27–66.09 ) | ( 26.11–76.69 ) | ( 0.00–23.17 ) | ( 0.00–31.02 ) | |
| p > 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Pará (PA) | 18.68 | 7.54 | 8.06 | 7.46 | 46.52 | 51.29 | 17.22 | 11.11 |
| (12.31–25.05) | (3.23–11.85) | (3.61–12.51) | (3.17–11.75) | ( 38.37–54.67 ) | ( 43.13–59.45 ) | ( 11.05–23.39 ) | ( 5.98–16.24 ) | |
| p <0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Amapá (AP) | 12.9 | 8.2 | 11.29 | 10.18 | 58.06 | 51.27 | 6.45 | 12.22 |
| (0.00–29.32) | (0.00–21.64) | (0.00–26.8) | (0.00–25) | ( 33.88–82.24 ) | ( 26.78–75.76 ) | ( 0.00–18.49 ) | ( 0.00–28.27 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Tocantins (TO) | 20 | 7.42 | 20 | 13.4 | 66.67 | 51.2 | 24.44 | 10.65 |
| (13.35–26.65) | (3.06–11.78) | (13.35–26.65) | (7.74–19.06) | ( 58.83–74.51 ) | ( 42.89–59.51 ) | ( 17.3–31.58 ) | ( 5.52–15.78 ) | |
| p <0.05 | p > 0.05 | p < 0.05 | p < 0.05 | |||||
| Northeast Region | ||||||||
| Maranhão (MA) | 18.37 | 7.32 | 13.61 | 8.57 | 36.05 | 51.33 | 21.09 | 10.21 |
| (13.22–23.52) | (3.85–10.79) | (9.05–18.17) | (4.85–12.29) | ( 29.66–42.44 ) | ( 44.68–57.98 ) | ( 15.66–26.52 ) | ( 6.18–14.24 ) | |
| p < 0.05 | p > 0.05 | p < 0.05 | p < 0.05 | |||||
| Piauí (PI) | 34.38 | 7.72 | 3.13 | 11.33 | 40.63 | 51.19 | 26.56 | 10.19 |
| (28.16–40.6) | (4.22–11.22) | (0.85–5.41) | (7.18–15.48) | ( 34.2–47.06 ) | ( 44.64–57.74 ) | ( 20.78–32.34 ) | ( 6.23–14.15 ) | |
| p < 0.05 | p < 0.05 | p < 0.05 | p < 0.05 | |||||
| Ceará (CE) | 19.33 | 8.03 | 8.36 | 9.08 | 48.51 | 51.26 | 21.93 | 11.08 |
| (13.62–25.04) | (4.1–11.96) | (4.36–12.36) | (4.93–13.23) | ( 41.29–55.73 ) | ( 44.04–58.48 ) | ( 15.95–27.91 ) | ( 6.54–15.62 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Rio Grande do Norte (RN) | 15.43 | 8.25 | 40.74 | 29.99 | 48.15 | 51.19 | 18.52 | 12.27 |
| (9.95–20.91) | (4.08–12.42) | (33.29–48.19) | (23.04–36.94) | ( 40.57–55.73 ) | ( 43.61–58.77 ) | ( 12.63–24.41 ) | ( 7.29–17.25 ) | |
| p < 0.05 | p < 0.05 | p > 0.05 | p > 0.05 | |||||
| Paraíba (PB) | 19.47 | 7.22 | 13.16 | 13.86 | 49.47 | 51.24 | 24.21 | 10.41 |
| (14.27–24.67) | (3.82–10.62) | (8.72–17.6) | (9.32–18.4) | ( 42.91–56.03 ) | ( 44.68–57.8 ) | ( 18.59–29.83 ) | ( 6.4–14.42 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Pernambuco (PE) | 19.8 | 7.79 | 28.12 | 21.11 | 41.32 | 51.16 | 18.83 | 10.8 |
| (14.04–25.56) | (3.92–11.66) | (21.62–34.62) | (15.21–27.01) | ( 34.21–48.43 ) | ( 43.94–58.38 ) | ( 13.18–24.48 ) | ( 6.32–15.28 ) | |
| p <0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Alagoas (AL) | 17.02 | 7.74 | 8.51 | 7.66 | 44.68 | 51.19 | 24.82 | 10.22 |
| (9.73–24.31) | (2.55–12.93) | (3.09–13.93) | (2.5–12.82) | ( 35.03–54.33 ) | ( 41.49–60.89 ) | ( 16.44–33.2 ) | ( 4.34–16.1 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Sergipe (SE) | 16.23 | 8.06 | 15.58 | 10.49 | 43.51 | 51.3 | 14.94 | 9.39 |
| (7.89–24.57) | (1.9–14.22) | (7.37–23.79) | (3.56–17.42) | ( 32.29–54.73 ) | ( 39.99–62.61 ) | ( 6.87–23.01 ) | ( 2.79–15.99 ) | |
| p > 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| Bahia (BA) | 21.16 | 8.44 | 9.57 | 8.16 | 46.1 | 51.15 | 20.4 | 10.22 |
| ( 17.24–25.08) | ( 5.77–11.11) | ( 6.75–12.39) | ( 5.53–10.79) | ( 41.32–50.88 ) | ( 46.35–55.95 ) | ( 16.53–24.27 ) | ( 7.31–13.13 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Southeast Region | ||||||||
| Minas Gerais (MG) | 23.6 | 9.37 | 45.82 | 34.49 | 47.59 | 51.13 | 25.03 | 10.76 |
| ( 20.75–26.45) | ( 7.41–11.33) | ( 42.48–49.16) | ( 31.3–37.68) | ( 44.24–50.94 ) | ( 47.78–54.48 ) | ( 22.12–27.94 ) | ( 8.68–12.84 ) | |
| p < 0.05 | p < 0.05 | p > 0.05 | p < 0.05 | |||||
| Espírito Santo (ES) | 21.82 | 7.98 | 39.55 | 27.09 | 49.09 | 51.33 | 25.91 | 9.33 |
| ( 12.65–30.99) | ( 1.97–13.99) | ( 28.7–50.4) | ( 17.23–36.95) | ( 38–60.18 ) | ( 40.24–62.42 ) | ( 16.19–35.63 ) | ( 2.88–15.78 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Rio de Janeiro (RJ) | 20.79 | 9.13 | 46.45 | 37.01 | 47.56 | 51.1 | 20 | 10.78 |
| ( 12.5–29.08) | ( 3.24–15.02) | ( 36.26–56.64) | ( 27.14–46.88) | ( 37.36–57.76 ) | ( 40.89–61.31 ) | ( 11.83–28.17 ) | ( 4.44–17.12 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p > 0.05 | |||||
| São Paulo (SP) | 25.27 | 9.2 | 66.46 | 60.04 | 49.25 | 51.21 | 26.27 | 10.93 |
| ( 21.92–28.62) | ( 6.97–11.43) | ( 62.82–70.1) | ( 56.26–63.82) | ( 45.39–53.11 ) | ( 47.35–55.07 ) | ( 22.87–29.67 ) | ( 8.52–13.34 ) | |
| p < 0.05 | p < 0.05 | p > 0.05 | p < 0.05 | |||||
| South Region | ||||||||
| Paraná (PR) | 23.43 | 8.51 | 81.38 | 78.41 | 48.15 | 51.24 | 20.87 | 9.93 |
| ( 19.27–27.59) | ( 5.77–11.25) | ( 77.56–85.2) | ( 74.37–82.45) | ( 43.25–53.05 ) | ( 46.34–56.14 ) | ( 16.88–24.86 ) | ( 7–12.86 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Santa Catarina (SC) | 22.81 | 7.87 | 87.84 | 86.05 | 47.95 | 51.33 | 27.68 | 10.37 |
| ( 18.02–27.6) | ( 4.8–10.94) | ( 84.11–91.57) | ( 82.1–90) | ( 42.25–53.65 ) | ( 45.63–57.03 ) | ( 22.57–32.79 ) | ( 6.89–13.85 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Rio Grande do Sul (RS) | 22.95 | 9.35 | 84.02 | 82.74 | 52.46 | 51.29 | 24.18 | 11.58 |
| ( 19.25–26.65) | ( 6.79–11.91) | ( 80.8–87.24) | ( 79.42–86.06) | ( 48.07–56.85 ) | ( 46.9–55.68 ) | ( 20.42–27.94 ) | ( 8.77–14.39 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Midwest Region | ||||||||
| Mato Grosso do Sul (MS) | 23.81 | 7.91 | 36.9 | 37.97 | 38.1 | 51.19 | 22.62 | 11.13 |
| ( 14.42–33.2) | ( 1.96–13.86) | ( 26.26–47.54) | ( 27.27–48.67) | ( 27.39–48.81 ) | ( 40.17–62.21 ) | ( 13.39–31.85 ) | ( 4.19–18.07 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p = 0.05 | |||||
| Mato Grosso (MT) | 17.91 | 7.48 | 25.37 | 25.67 | 47.76 | 51.2 | 21.64 | 10.29 |
| ( 11.58–24.24) | ( 3.14–11.82) | ( 18.19–32.55) | ( 18.46–32.88) | ( 39.52–56 ) | ( 42.95–59.45 ) | ( 14.84–28.44 ) | ( 5.28–15.3 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Goiás (GO) | 17.92 | 8.39 | 30.81 | 27.75 | 51.45 | 51.1 | 17.34 | 10.02 |
| ( 13.13–22.71) | ( 4.93–11.85) | ( 25.04–36.58) | ( 22.15–33.35) | ( 45.2–57.7 ) | ( 44.85–57.35 ) | ( 12.61–22.07 ) | ( 6.27–13.77 ) | |
| p < 0.05 | p > 0.05 | p > 0.05 | p < 0.05 | |||||
| Federal District (DF) | 20 | 9.52 | 30.48 | 23.29 | 51.43 | 51.12 | 16.19 | 10.96 |
| * | * | * | * | * | * | * | * | |
| * | * | * | * | * | * | * | * | |
| Brazil | 22.25 | 8.49 | 48.79 | 36.71 | 47.97 | 51.21 | 23.05 | 10.7 |
| ( 21.16–23.34) | ( 7.76–9.22) | ( 47.48–50.1) | ( 35.44–37.98) | ( 46.66–49.28 ) | ( 49.9–52.52 ) | ( 21.94–24.16 ) | ( 9.89–11.51 ) | |
| p < 0.05 | p < 0.05 | p < 0.05 | p < 0.05 | |||||
*Confidence interval 95% not calculated because the values are constant (a single municipality); Down: individuals with Down syndrome; No Down: individuals without Down syndrome. p < 0.05. Z-test was used for comparison between the Down and No Down groups.
Source: SINASC.