Extended Data Table 6 |.
Toxicities resulting in serious adverse events (SAEs), determined by the treating physician to be related to the treatment, reported among patients who received protocol therapy
| Adverse Event | Any Grade | Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 |
|---|---|---|---|---|---|---|
| Adrenal insufficiency | 2 (7%) | 0 | 1 | 1 | 0 | 0 |
| Pancreatitis | 2 (7%) | 0 | 0 | 2 | 0 | 0 |
| Creatinine phosphokinase increased | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Cardiac troponin I increased | 1 (4%) | 1 | 0 | 0 | 0 | 0 |
| Colitis | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Diarrhea | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Fever | 1 (4%) | 0 | 1 | 0 | 0 | 0 |
| Generalized muscle weakness | 1 (4%) | 0 | 1 | 0 | 0 | 0 |
| Immune-mediated duodenitis | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Lung infection | 1 (4%) | 0 | 0 | 0 | 1 | 0 |
| MS/connective tissue disorder | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Myositis | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
| Upper GI hemorrhage | 1 (4%) | 0 | 0 | 1 | 0 | 0 |
Adverse event severity was scored using National Cancer Institute CTCAE version 4.0.