Table 2.
Colocalization analysis of S1PR1 expression with breast cancer and ER subtypes.
| Outcome | nSNPs | PP.H0 | PP.H1 | PP.H2 | PP.H3 | PP.H4 |
|---|---|---|---|---|---|---|
| Breast cancer | 6475 | 1.51E−28 | 1.30E−27 | 0.102756 | 0.8841246 | 0.0131194 |
| ER+ breast cancer | 6476 | 1.22E−27 | 2.34E−28 | 0.8336529 | 0.1594487 | 0.0068985 |
| ER− breast cancer | 5076 | 1.03E−27 | 2.58E−28 | 0.70362 | 0.1753183 | 0.1210617 |
eQTL = expression quantitative trait locus, ER = estrogen receptor, nSNPs = number of single-nucleotide polymorphisms, PP.H = posterior probability for hypothesis, where PP.H4 > 0.8 indicates strong evidence for shared causal variants.