Table 7.
Different lipophilicity characteristics of common medicinal herbal compounds with high affinity to GP63, FPPS, and NMT proteins.
| Lipophilicity | Log Po/w (iLOGP) | Log Po/w (XLOGP3) | Log Po/w (WLOGP) | Log Po/w (MLOGP) | Log Po/w (SILICOS-IT) | Consensus Log Po/w |
|---|---|---|---|---|---|---|
| Withaperuvin D | 1.8 | -0.35 | 0.92 | 0.48 | 2.06 | 0.98 |
| Lagerstannin A | -0.39 | 0.71 | 0.39 | -2.97 | -2.17 | -0.89 |
| Strictinin | 0.92 | 0.07 | -0.3 | -2.42 | -2.15 | -0.77 |
| Chelidimerine | 5.31 | 7.67 | 6.86 | 4.02 | 7.03 | 6.18 |
| Friedelin | 4.52 | 9.8 | 8.46 | 6.92 | 7.52 | 7.44 |
| Hypericin | 3.1 | 5.71 | 5.76 | 1.36 | 5.37 | 4.26 |
| Amentoflavone | 3.06 | 5.04 | 5.13 | 0.25 | 4.61 | 3.62 |
| Protohypericin | 1.76 | 3.79 | 3.82 | 1.33 | 4.71 | 3.08 |
| Luteolin 3'-o-glucuronide | 1.69 | 1.22 | -0.15 | -2.12 | -0.57 | 0.01 |
GP63, glycoprotein 63; FPPS, farnesyl diphosphate synthase; NMT, N-myristoyltransferase.