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. 2025 Aug 27;15:1550960. doi: 10.3389/fonc.2025.1550960

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Copyright © 2025 Zhang, Jiang, Wu, Zhang, Wang, Yang, Li, He and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological images in three panels labeled A, B, and C. Panel A shows tissue stained with purple hues, typical of hematoxylin and eosin staining, revealing different cell structures. Panels B and C display brown-stained tissues, likely immunohistochemical staining, highlighting specific protein expressions. White spaces in all panels indicate the separation within tissue structures. — Pathological findings: (A) HE staining of adenocarcinoma, adenocarcinoma cells formed irregular adenoid structures, and pathologic nuclear schizophrenia was common. Immunohistochemistry: (B) CDX2 positive staining, (C) CK20 positive staining.