Table 2.
Relationship between Claudin 18 protein expression in colorectal cancer tissues and clinical pathological parameters.
| Characteristic | Category | Positive cases, n (%) | Negative cases, n (%) | Total, n | P value |
|---|---|---|---|---|---|
| Gender | Female | 23 (19.5) | 30 (25.4) | 53 | 0.144 |
| Male | 37 (31.4) | 28 (23.7) | 65 | ||
| Age | <60 | 9 (7.6) | 20 (16.9) | 29 | 0.014 |
| ≥60 | 51 (43.2) | 38 (32.2) | 89 | ||
| T stage | T1 | 2 (1.7) | 1 (0.8) | 3 | 0.399 |
| T2 | 3 (2.5) | 8 (6.8) | 11 | ||
| T3 | 20 (16.9) | 17 (14.4) | 37 | ||
| T4 | 35 (29.7) | 32 (27.1) | 67 | ||
| N stage | N0 | 25 (21.2) | 25 (21.2) | 50 | 0.875 |
| N+ | 35 (29.7) | 33 (28.0) | 68 | ||
| M stage | M0 | 58 (49.2) | 56 (47.5) | 114 | 1 |
| M1 | 2 (1.7) | 2 (1.7) | 4 | ||
| Histological type | Colon cancer | 32 (27.1) | 31 (26.3) | 63 | 0.99 |
| Rectal cancer | 28 (23.7) | 27 (22.9) | 55 | ||
| Differentiation | High | 16 (13.6) | 18 (15.3) | 34 | 0.344 |
| Moderate | 42 (35.6) | 40 (33.9) | 82 | ||
| Low | 2 (1.7) | 0 (0.0) | 2 | ||
| MMR status | pMMR | 38 (32.2) | 28 (23.7) | 66 | 0.1 |
| dMMR | 22 (18.6) | 30 (25.4) | 52 | ||
| Lymphatic invasion* | No | 14 (12.0) | 24 (20.5) | 38 | 0.042 |
| Yes | 45 (38.5) | 34 (29.1) | 79 | ||
| Total | 60 (50.8) | 58 (49.2) | 118 |
*Data on lymphatic invasion status was unavailable for one patient.