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. Author manuscript; available in PMC: 2006 Mar 16.
Published in final edited form as: J Biol Chem. 2005 Jul 1;280(37):32133–32140. doi: 10.1074/jbc.M506104200

Figure 1. Sites of O-fucosylation on mouse Notch1.

Figure 1

The extracellular domain of mouse Notch1 contains multiple sites for O-fucosylation based on the consensus sequence C2X4-5(S/T)C3, most of which appear to be modified (6). These sites are conserved to varying degrees when compared to Notch receptors with 36 EGF repeats (indicated by the number of * from a total of 15 homologues) (adapted from (7)). The O-fucose sites mutated in this study are indicated by number. The location of the ligand binding domain (24), the negative regulatory Abruptex region (26), and a putative region of flexibility (25) of the Notch protein are also indicated.