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. 2025 Aug 27;16:1646038. doi: 10.3389/fimmu.2025.1646038

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Copyright © 2025 Liu, Song, Du and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Forest plot comparing drugs across several categories: immune checkpoint inhibitors, antibody-drug conjugates, alkylating agents, antimetabolites, targeted kinase inhibitors, and other drugs. Each drug's effect size is represented with a point estimate and a confidence interval along the x-axis, indicating variability and statistical significance. Notable drugs include Pembrolizumab, Enfortumab Vedotin, and Pralatrexate, with varying levels of relative risk ratios (ROR). — Disproportionality analysis of significant SJS/TEN reports associated with anticancer therapies. * indicated the alerts of SJS/TEN do not include in the drug package inserts.