Table 3.
Univariate Cox proportional hazard analysis for overall survival in patients with IDH-mutant WHO grade 2 and grade 3 astrocytoma. Univariate analysis of the entire study cohort was conducted using log-rank tests to evaluate the relationship between clinical and histopathological parameters and overall survival. The results are reported as hazard ratios with 95% confidence intervals. P values are given, asterisks indicate p ≤ 0.05
| Univariate analysis for WHO grade 2 and 3 astrocytoma | ||||
|---|---|---|---|---|
| Variable | Type of variable | Overall survival | ||
| Hazard ratio | 95% confidence interval | p-value | ||
| WHO grade | grade 3 (versus grade 2) | 3.14 | 1.03–9.92 | *0.04 |
| Surgery | biopsy (versus resection) | 1.38 | 0.48–4.53 | 0.57 |
| Histologic features | ||||
| Mitotic count (continuous) | continuous | 1.65 | 0.95–2.79 | 0.06 |
| Ki67 proliferation index | continuous | 1.08 | 1.01–1.14 | *0.01 |
| Demographics | ||||
| Sex | male (versus female) | 0.98 | 0.34–2.76 | 0.96 |
| Age (years) | continuous (older) | 0.98 | 0.92–1.04 | 0.57 |
| Clinical and Radiological markers | ||||
| Contrast enhancement | enhancing (versus non-enhancing) | 4.33 | 1.31–15.47 | *0.02 |
| KPS at diagnosis | ≤ 80 (versus higher) | 1.03 | 0.15–4.12 | 0.97 |