Table 2.
Group comparison of risk factors for WMH stratified by subtype and Fazekas score.
| Variable | PWMH | DWMH | ||||
|---|---|---|---|---|---|---|
| Score 0–1 (n = 261) |
Score 2–3 (n = 279) |
p | Score 0–1 (n = 391) |
Score 2–3 (n = 149) |
p | |
| Age (years) | 62.00(54.50 ~ 71.00) | 73.00(67.00 ~ 80.00) | <0.0001 | 68.00(57.00 ~ 76.00) | 72(65.50 ~ 79.00) | <0.0001 |
| Sex distribution | 0.28 | 0.61 | ||||
| Male [n (%)] | 131 (50.19%) | 153 (54.84%) | 203(51.92%) | 81(54.36%) | ||
| Female [n (%)] | 130 (49.81%) | 126 (45.16%) | 188(48.08%) | 68(45.64%) | ||
| Hypertension | <0.0001 | <0.0001 | ||||
| Yes [n (%)] | 120 (45.98%) | 211 (75.63%) | 217(55.50%) | 114(76.51%) | ||
| No [n (%)] | 141 (54.02%) | 68 (24.37%) | 174(44.50%) | 35(23.49%) | ||
| Coronary heart disease | 0.001 | 0.10 | ||||
| Yes [n (%)] | 32 (12.26%) | 64 (22.94%) | 63(16.11%) | 33(22.15%) | ||
| No [n (%)] | 229 (87.74%) | 215 (77.06%) | 328(83.89%) | 116(77.85%) | ||
| Diabetes mellitus | 0.04 | 0.009 | ||||
| Yes [n (%)] | 88 (33.72%) | 118 (42.29%) | 136(34.78%) | 70(46.98%) | ||
| No [n (%)] | 173 (66.28%) | 161 (57.71%) | 255(65.32%) | 79(53.02%) | ||
| Smoking history | 0.27 | 0.03 | ||||
| Yes [n (%)] | 80 (30.65%) | 98 (35.13%) | 118(30.18%) | 60(40.27%) | ||
| No [n (%)] | 181 (69.35%) | 181 (64.87%) | 273(69.82%) | 89(59.73%) | ||
| Alcohol consumption | 0.19 | 0.03 | ||||
| Yes [n (%)] | 68 (26.05%) | 87 (31.18%) | 102(26.09%) | 53(35.57%) | ||
| No [n (%)] | 193 (73.95%) | 192 (68.82%) | 289(73.91%) | 96(64.43%) | ||
| Creatinine abnormality | 0.0001 | 0.003 | ||||
| Yes [n (%)] | 33 (12.64%) | 72 (25.81%) | 64(16.37%) | 41(27.52%) | ||
| No [n (%)] | 228 (87.36%) | 207 (74.19%) | 327(83.63%) | 108(72.48%) | ||
| Uric acid abnormality | 0.11 | 0.04 | ||||
| Yes [n (%)] | 53 (20.31%) | 73 (26.16%) | 82(20.97%) | 44(29.53%) | ||
| No [n (%)] | 208 (79.69%) | 206 (73.84%) | 309(79.03%) | 105(70.47%) | ||
| Cystatin C (Cys-C) abnormality | 0.003 | 0.0008 | ||||
| Yes [n (%)] | 39 (14.94%) | 70 (25.09%) | 65(16.62%) | 44(29.53%) | ||
| No [n (%)] | 222 (85.06%) | 209 (74.91%) | 326(83.38%) | 105(70.47%) | ||
| β2-microglobulin (β2-MG) abnormality | 0.02 | 0.0008 | ||||
| Yes [n (%)] | 46 (17.62%) | 72 (25.81%) | 71(18.16%) | 47(31.54%) | ||
| No [n (%)] | 215 (82.38%) | 207 (74.19%) | 320(81.84%) | 102(68.46%) | ||
| Hyperlipidemia | 0.09 | 0.04 | ||||
| Yes [n (%)] | 140 (53.64%) | 129 (46.24%) | 205(52.43%) | 64(42.95%) | ||
| No [n (%)] | 121 (46.36%) | 150 (53.76%) | 186(47.57%) | 85(57.05%) | ||
Bold values indicate statistically significant results (p < 0.05).