Table 3.

Independent risk factor analysis for moderate-to-severe Fazekas-scored WMH across subtypes.

Variable	PWMH			DWMH
	β	OR(95%CI)	p	β	OR(95%CI)	p
Age (per year)	0.088	1.09 (1.07–1.12)	<0.0001	0.033	1.034(1.013 ~ 1.056)	0.001
Sex (Male)	−0.039	0.96 (0.55–1.67)	0.888	−0.615	0.541(0.287 ~ 0.986)	0.050
Hypertension	1.070	2.92 (1.93–4.43)	<0.0001	0.743	2.102(1.341 ~ 3.350)	0.001
Coronary heart disease	0.099	1.10 (0.65–1.89)	0.716	−0.064	0.938(0.552 ~ 1.566)	0.809
Diabetes mellitus	0.138	1.15 (0.76–1.74)	0.513	0.440	1.553(1.022 ~ 2.363)	0.039
Smoking history	0.230	1.26 (0.68–2.33)	0.462	0.685	1.983(1.037 ~ 3.876)	0.041
Alcohol consumption	0.352	1.42 (0.79–2.57)	0.241	0.447	1.564(0.852 ~ 2.895)	0.151
Creatinine abnormality	0.732	2.07 (1.18–3.72)	0.012	0.172	1.188(0.681 ~ 2.042)	0.538
Uric acid abnormality	0.341	1.41 (0.86–2.31)	0.174	0.365	1.440(0.883 ~ 2.329)	0.140
Cys-C abnormality	−0.657	0.52 (0.27–0.98)	0.045	−0.067	0.935(0.494 ~ 1.735)	0.833
β2-MG abnormality	0.088	1.09 (1.07–1.12)	0.347	0.579	1.785(1.022 ~ 3.097)	0.040
Hyperlipidemia	−0.039	0.96 (0.55–1.67)	0.477	−0.422	0.656(0.430 ~ 0.996)	0.049

Bold values indicate statistically significant results (p < 0.05).