Table 4.
Multivariable linear regression analysis of risk factors for WMH volumes based on anatomical subtypes.
| Variable | Ventricular | Periventricular | Juxtacortical | DWMH | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| β | t | p | β | t | p | β | t | p | β | t | p | |
| Age (per year) | 0.085 | 7.021 | **** | 0.236 | 6.134 | **** | 0.010 | 2.850 | 0.005 | 0.018 | 1.457 | 0.146 |
| Sex (Male) | 0.200 | 0.569 | 0.570 | −0.469 | 0.420 | 0.675 | −0.148 | 1.418 | 0.157 | −0.458 | 1.276 | 0.202 |
| Hypertension | 1.209 | 4.501 | **** | 3.618 | 4.239 | **** | 0.170 | 2.127 | 0.034 | 0.537 | 1.959 | 0.051 |
| Coronary heart disease | −0.002 | 0.006 | 0.995 | 0.636 | 0.589 | 0.556 | 0.232 | 2.296 | 0.022 | 0.076 | 0.218 | 0.827 |
| Diabetes mellitus | 0.695 | 1.743 | 0.082 | 3.073 | 2.426 | 0.016 | 0.152 | 1.283 | 0.200 | 0.738 | 1.813 | 0.070 |
| Smoking history | 0.479 | 1.252 | 0.211 | 0.708 | 0.582 | 0.561 | 0.11 | 1.027 | 0.305 | 0.414 | 1.060 | 0.290 |
| Alcohol consumption | 0.132 | 0.496 | 0.620 | 0.240 | 0.284 | 0.776 | 0.051 | 0.641 | 0.522 | 0.439 | 1.619 | 0.106 |
| Creatinine abnormality | 0.517 | 1.439 | 0.151 | 1.714 | 1.503 | 0.133 | 0.280 | 2.626 | 0.009 | 0.713 | 1.945 | 0.052 |
| Uric acid abnormality | 0.564 | 1.825 | 0.069 | 1.385 | 1.412 | 0.159 | 0.086 | 0.940 | 0.348 | 0.363 | 1.150 | 0.251 |
| Cys-C abnormality | 0.158 | 0.392 | 0.695 | −0.917 | 0.718 | 0.473 | −0.117 | 0.980 | 0.327 | −0.005 | 0.013 | 0.990 |
| β2-MG abnormality | 0.378 | 0.287 | 0.287 | −0.433 | 0.384 | 0.701 | 0.149 | 1.412 | 0.159 | 0.378 | 1.045 | 0.297 |
| Hyperlipidemia | −0.274 | 0.286 | 0.286 | −1.088 | 1.335 | 0.183 | −0.194 | 2.540 | 0.011 | −0.783 | 2.988 | 0.003 |
****p < 0.0001. Bold values indicate statistically significant results (p < 0.05).