Table 2.
MBD2 genotypes, menopausal status and breast cancer risk in Caucasians
| MBD2 genotype | Cases (n = 393) | Controls (n = 436) | Crude OR (95% CI) | ORa (95% CI) |
| SNP 1 (rs1259938) | ||||
| All women | ||||
| G/G | 210 (53.4) | 226 (51.8) | 1.00 | 1.00 |
| G/A | 158 (40.2) | 179 (41.1) | 0.95 (0.71–1.27) | 0.94 (0.70–1.26) |
| A/A | 25 (6.4) | 31 (7.1) | 0.86 (0.49–1.52) | 0.86 (0.49–1.54) |
| G/A + A/A | 183 (46.6) | 210 (48.2) | 0.94 (0.71–1.23) | 0.94 (0.71–1.24) |
| Premenopausal women | ||||
| G/G | 59 (67.1) | 69 (47.3) | 1.00 | 1.00 |
| G/A | 25 (28.4) | 65 (44.5) | 0.43 (0.24–0.77) | 0.40 (0.22–0.74) |
| A/A | 4 (4.6) | 12 (8.2) | 0.39 (0.12–1.26) | 0.39 (0.12–1.29) |
| G/A + A/A | 29 (33.0) | 77 (52.7) | 0.42 (0.24–0.73) | 0.41 (0.23–0.72) |
| Postmenopausal women | ||||
| G/G | 151 (49.5) | 157 (54.1) | 1.00 | 1.00 |
| G/A | 133 (43.6) | 114 (39.3) | 1.24 (0.88–1.74) | 1.24 (0.88–1.75) |
| A/A | 21 (6.9) | 19 (6.6) | 1.16 (0.59–2.27) | 1.15 (0.58–2.29) |
| G/A + A/A | 154 (50.5) | 134 (45.9) | 1.23 (0.90–1.70) | 1.24 (0.90–1.72) |
| SNP 2 (rs609791) | ||||
| All women | ||||
| C/C | 243 (63.9) | 260 (61.6) | 1.00 | 1.00 |
| C/G | 120 (31.6) | 140 (33.2) | 0.92 (0.68–1.24) | 0.92 (0.68–1.24) |
| G/G | 17 (4.5) | 22 (5.2) | 0.83 (0.43–1.59) | 0.85 (0.44–1.64) |
| C/G + G/G | 237 (36.1) | 162 (38.4) | 0.90 (0.68–1.21) | 0.91 (0.68–1.22) |
| Premenopausal women | ||||
| C/C | 60 (70.6) | 80 (56.3) | 1.00 | 1.00 |
| C/G | 20 (23.5) | 55 (38.7) | 0.48 (0.26–0.89) | 0.47 (0.26–0.88) |
| G/G | 5 (5.9) | 7 (5.0) | 0.95 (0.29–3.15) | 1.02 (0.30–3.49) |
| C/G + G/G | 25 (29.4) | 62 (43.7) | 0.54 (0.30–0.95) | 0.54 (0.30–0.96) |
| Postmenopausal women | ||||
| C/C | 183 (62.0) | 180 (64.3) | 1.00 | 1.00 |
| C/G | 100 (33.9) | 85 (30.4) | 1.16 (0.81–1.65) | 1.15 (0.80–1.64) |
| G/G | 12 (4.1) | 15 (5.3) | 0.79 (0.36–1.73) | 0.80 (0.36–1.76) |
| C/G + G/G | 112 (38.0) | 100 (35.7) | 1.10 (0.78–1.55) | 1.10 (0.78–1.55) |
Values are expressed as n (%). aAdjusted for age (as a continuous variable), body mass index (<25 kg/m2, 25–29.99 kg/m2, >29.99 kg/m2), family history of breast cancer in first-degree relatives, menopausal status, family income (tertiles based on distribution of controls), lifetime months of breast feeding (never, 1–5, 6–15, ≥ 15 months) and study site. CI, confidence interval; OR, odds ratio.