Table 1.

Likelihood ratios for the S384F variant

	LR for S384F (BRCA2)
Co-segregation	3.236
Co-occurrence	0.00000111
Loss of heterozygosity	0.00391
Overall LR	1.4 × 10-8

An overall likelihood ratio (LR) of <0.01 is considered to prove that the variant is neutral [3].