Table 1.
Differences in the expression of hypoxia related proteins, microvasculature and proliferation in fibroepithelial breast tumors
| Marker | Fibroadenoma (n = 30) | Phyllodes tumor (n = 37) | P valuea |
| Stroma | |||
| HIF-1α | 2 (7%) | 19 (51%) | 0.001 |
| CAIX | 0 (0%) | 2/36 (6%) | 0.497 |
| VEGF | 7 (23%) | 17 (47%) | 0.074 |
| Ki67 | 1 (3%) | 17 (47%) | <0.001 |
| Hot-spot microvessel count | 13 (43%) | 22/35 (63%) | 0.140 |
| Global microvessel count | 13 (43%) | 20/35 (57%) | 0.324 |
| p53 | 0(0%) | 7/36(19%) | 0.014 |
| Epithelium | |||
| HIF-1α | 0 (0%) | 15/35 (43%) | <0.001 |
| CAIX | 0 (0%) | 9/35 (26%) | 0.003 |
| VEGF | 22 (73%) | 22/36 (61%) | 0.432 |
| Ki67 | 2 (7%) | 2/36 (6%) | 1.000 |
| p53 | 0(0%) | 0(0%) | - |
Due to empty blocks, repeated unsuccessful staining attempts or too little epithelium in a malignant tumor, numbers varied slightly for some stainings. Dichotomized values were used. aUsing the chi-square test, P values below 0.05 were regarded as significant. HIF-1α = hypoxia-inducible factor 1 alpha, CAIX = carbonic anhydrase IX, VEGF = vascular endothelial growth factor.