Table 1.

Compartment gene sets are enriched for candidate genes of ocular diseases

	Disease-associated genes on array	Disease-associated genes expressed in affected compartment	Percentage of known disease-associated genes identified	Average fold enrichment compared to total number of genes in interval	P-value
Lens	15	8	53	2.4	0.002
Cornea	13	9	69	2.0	0.005
Retina	42	23	55	2.3	0.0004

Arrays were standardized to the same median intensity and genes exhibiting minimum intensities of 2,500 in any compartment were identified. Genetic diseases affecting the lens, cornea, or retina were collated from the RetNet [71] and Online Mendelian Inheritance in Man [72] databases, along with their cytogenetic map positions. The table indicates the number of cloned disease genes on the arrays, the number contained in a given compartment gene set, the percentage of known disease genes included in the signatures, the average fold enrichment compared to the total number of genes in each cytogenetic interval, and the statistical significance of this enrichment (using the hypergeometric distribution).