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. 2025 Sep 4;13:e20003. doi: 10.7717/peerj.20003

Table 2. Baseline NLR association with treatment.

Treatment Lymphocyte_Count_1 (Mean ± SD) Neutrophil_Count_1 (Mean ± SD) Neutrophil-to-Lymphocyte ratio (Mean ± SD) Beta p-value (NLR)
Hydroxychloroquine 2.25 ± 0.74 7.88 ± 4.20 8.33 ± 8.94 −0.042 0.620
Chloroquine 2.02 ± 0.59 8.14 ± 4.42 8.86 ± 7.71 −0.013 0.762
Azithromycin 2.36 ± 5.10 8.25 ± 4.52 8.81 ± 8.84 −0.008 0.339
Kaletra 2.26 ± 0.90 8.12 ± 4.24 8.50 ± 7.89 −0.029 0.602
Tocilizumab 2.17 ± 0.63 7.67 ± 4.00 8.27 ± 8.63 −0.081 0.031**
Favipiravir 2.25 ± 0.74 7.99 ± 3.88 9.01 ± 9.78 −0.028 0.321
Remdesivir 1.93 ± 0.48 7.96 ± 3.38 9.82 ± 7.13 −0.021 0.426
Ribavirin 2.22 ± 0.88 8.35 ± 4.74 9.20 ± 9.13 −0.066 0.115
IVIG 2.21 ± 0.72 7.97 ± 4.76 7.68 ± 5.45 −0.000 0.995
Interferon 2.31 ± 0.99 8.04 ± 4.42 8.12 ± 6.97 0.068 0.050
Ostilomavir 2.78 ± 9.22 8.02 ± 4.22 7.54 ± 5.33 −0.091 0.004**
β-Lactam/BLI 2.24 ± 0.77 7.79 ± 3.94 8.30 ± 8.24 0.054 0.055
Cephalosporine 2.46 ± 6.14 8.10 ± 4.57 8.38 ± 8.40 −0.008 0.771
Carbapenem 2.50 ± 6.77 8.16 ± 4.24 8.48 ± 7.85 −0.046 0.175
Aminoglycosides 2.46 ± 1.09 7.81 ± 3.23 8.38 ± 8.40 −0.002 0.945
Colistin 2.28 ± 0.72 8.18 ± 4.22 8.24 ± 7.52 −0.026 0.399
Ceftalazone-Avibactam 2.20 ± 0.61 9.40 ± 5.49 10.15 ± 10.56 −0.020 0.506
Ceftazidime-Tazobactam 2.18 ± 0.48 9.37 ± 4.48 9.26 ± 8.27 −0.012 0.667
Vancomycin 2.51 ± 7.21 8.15 ± 4.23 8.63 ± 7.84 −0.021 0.476
Linezolid 2.22 ± 0.72 8.30 ± 4.43 9.44 ± 8.91 −0.064 0.029**
Antifungal 2.22 ± 0.59 7.91 ± 4.30 8.31 ± 8.49 0.007 0.796

Notes.

NLR values represent baseline measurements at ICU admission (Day 1). Significance (p-value) reflects differences in baseline NLR between patients who received the specified treatment versus those who did not, derived from a Generalized Linear Model (GLM) adjusted for age, gender, and comorbidities. This analysis does not evaluate longitudinal NLR changes post-treatment.

**

Shows statistical significance, p < 0.05.