Table 1.
Genes with significantly altered basal bilateral levels in the LDH of CAR-P3 as compared to their bilateral expressions in the LDH of CONT and CAR-P12 animals [one-way ANOVAs, (with the Benjamini and Hochberg's FDR correction procedure set at the P-value cutoff of 0.05) followed by Tukey's post-hoc tests (with the same P-cutoff value) in the implementation of GeneSpring GX software (Agilent, Palo Alto, CA).)]. Differences in gene expression are presented as ratios between CAR-P3 and CONT, CARP-12 and CONT, and CAR-P3 and CAR-P12 groups. Statistically insignificant differences are marked as 'ND' The comparisons are based on the microarray profiling that employed 5 slides for comparison of CONT and CAR-P3 samples and another 5 slides for comparison of CONT and CAR-P12 samples.
| Genes | Left LDH (ipsilateral to the site of neonatal injury) | Right LDH (contralateral to the site of neonatal injury) | ||||
| CAR-P3/CONT | CAR-P12/CONT | CAR-P3/CAR-P12 | CAR-P3/CONT | CAR-P12/CONT | CAR-P3/CAR-P12 | |
| GABAB1d | 1.6 | ND | 2.1 | 2.2 | ND | 2.2 |
| GAD65 | 2.1 | 1.8 | 1.2 | 2.5 | 1.4 | 1.8 |
| A1 aden. rec. | 2.2 | ND | 2.0 | 1.55 | ND | 1.64 |
| Pre-proenkephalin | 2.0 | ND | 1.5 | 1.5 | ND | 1.9 |
| σ rec. | 3.2 | ND | 2.9 | 2.3 | ND | 2.5 |
| NPYR6 | 3.5 | ND | 2.7 | 2.8 | ND | 2.8 |
| γ-tachikinin | 2.1 | ND | 2.3 | 2.7 | ND | 3.1 |
| δ-preporotachykinin | 2.2 | 1.5 | 1.5 | 3.1 | 1.8 | 1.7 |
| α2b adr. rec. | 2.0 | 1.6 | 1.2 | 3.0 | 1.7 | 1.8 |
| β3 adr. rec. | 2.2 | 1.7 | 1.3 | 3.0 | 1.7 | 1.8 |
| 5-HT5a | 2.0 | ND | 1.8 | 1.6 | ND | 1.2 |
| CCKR-1 | 2.2 | 1.8 | 1.2 | 3.4 | 2.3 | 1.5 |
| IL-10 | 4.3 | 1.6 | 2.6 | 2.0 | 1.4 | 1.4 |
| NR2B | 2.2 | 3.7 | 0.6 | 2.4 | 5.0 | 0.5 |
| SstR2 | 2.2 | 3.2 | 0.7 | 3.9 | 5.3 | 0.7 |