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. 2025 May 29;49(15):4392–4402. doi: 10.1007/s00266-025-04809-9

Table 4.

Injection site pain and common treatment reactions reported by the investigator

Tear trough Palpebromalar groove Crow’s feet Outer canthus Brow
VAS during injection n 113 78 43 52 20
Mean ± sd 20.3 ± 18.7 26.1 ± 15.7 24.8 ± 15.6 26.7 ± 16.3 22.8 ± 15.4
VAS at end of visit n 114 78 43 52 20
Mean ± sd 0.4 ± 2.2 0.3 ± 1.8 0.1 ± 0.8 0.1 ± 0.7 0.0 ± 0.0
Common treatment reactions n 116 78 48 53 20

Mild bruising

Mild swelling

Mild redness

Mild lumps and bumps

Moderate redness

17 (14.7%)

9 (7.8%)

5 (4.3%)

1 (0.9%)

1 (0.9%)

7 (9.0%)

2 (2.6%)

0 (0.0%)

0 (0.0%)

1 (1.3%)

5 (10.4%)

1 (2.1%)

0 (0.0%)

7 (14.6%)

1 (2.1%)

6 (11.3%)

1 (1.9%)

0 (0.0%)

1 (1.9%)

1 (1.9%)

2 (10.0%)

4 (20.0%)

0 (0.0%)

1 (5.0%)

0 (0.0%)

SD, standard deviation; VAS, Visual Analog Scale