Figure 3.

Model predictions of transmission of ART drug resistance by relative fitness of strains. Predictions of the spread of transmitted (primary) ART resistance under various scenarios, using a simplified ART model (see Endnote). Model output is 10 years after ART introduction. ART is introduced once the epidemic has reached equilibrium. Superinfection refers to the infection with ART-resistant HIV of individuals previously infected with ART-sensitive HIV and successfully undergoing treatment. These are the only individuals without viral outgrowth, and thus will have a pool of target cells rendering them susceptible to infection. Evolution of drug resistance within an individual is at a rate of 10% per year.