Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

[Preprint]. 2025 Sep 4:2025.09.02.25334770. [Version 1] doi: 10.1101/2025.09.02.25334770

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.

PMC Copyright notice

Figure 3. — Correlations between baseline biomarkers and clinical decline in ALS. (A, B) Higher baseline NfL levels (pg/mL) are associated with greater monthly decline in slow vital capacity (Δ sVC %/month) and ALSFRS-R (Δ ALSFRS-R/month), respectively. (C, D) Higher baseline MUNIX-10 scores are associated with slower decline in ALSFRS-R (D), but show no significant association with Δ SVC (C). The most pronounced correlations were found for baseline NfL/MUNIX-10 ratio with Δ SVC (E) and Δ ALSFRS-R (F). Each panel shows individual data points, linear regression lines (blue), 95% confidence intervals (gray shading), and corresponding Spearman correlation coefficients (rho) with p-values adjusted for multiplicity by Bonferroni-Holm.