Figure 1.

Phage enrichment in vivo. A cDNA phage pool that was preselected for ex vivo binding to bone marrow cells was injected into the tail vein of mice. After 10 min of circulation, the mice were perfused through the heart, and phage was rescued from various organs, amplified, and used for subsequent rounds of selection. Fold enrichment of selected phage pool relative to the unselected cDNA phage library pool is shown.